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首页> 外文期刊>Journal of Clinical Microbiology >Molecular and Phenotypic Characteristics of Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus Isolates from Patients with Septic Arthritis
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Molecular and Phenotypic Characteristics of Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus Isolates from Patients with Septic Arthritis

机译：败血症性关节炎患者耐甲氧西林和万古霉素金黄色葡萄球菌分离株的分子和表型特征

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摘要

Staphylococcus aureus is one of the most common pathogens in community- and hospital-associated infections and frequently causes severe and intractable infections in osteoarticular tissues. S. aureus isolates that are resistant to methicillin (meticillin) (MRSA isolates) and intermediately resistant to vancomycin (VISA isolates) have emerged. In this report, we described two patients, one female and one male, diagnosed with septic arthritis due to S. aureus infections. A total of 13 MRSA isolates were obtained from these two patients. All but one isolate belonged to the VISA group. All seven isolates from the female patient were determined to be community associated, multilocus sequence type (MLST) 59, and staphylococcal cassette chromosome mecA (SCCmec) type IV; had direct repeat units (DRUs) of nine repeats; were spa type t437; and were susceptible to sulfa and quinolone antibiotics. The other six isolates, from the male patient, were determined to be hospital associated, MLST 239, and SCCmec type III; had DRUs of 14 repeats; were spa type t037; and were resistant to sulfa and quinolone antibiotics. All 13 MRSA isolates were in agr group I, were pvl negative, and showed no evidence of any association between vancomycin resistance and autolysis.
机译：金黄色葡萄球菌是社区和医院相关感染中最常见的病原体之一，并经常在骨关节组织中引起严重且难治的感染。 S。已经出现了对甲氧西林（美西林）有抗性的金黄色葡萄球菌（MRSA分离物）和对万古霉素（VISA分离物）有中度抗性的金黄色葡萄球菌。在本报告中，我们描述了两名因 S而被诊断为败血性关节炎的女性，一名男性。金黄色感染。从这两名患者中总共获得了13种MRSA分离株。除一个隔离株外，所有隔离株均属于VISA组。该女性患者的所有7种分离株均被确定为社区相关型，多基因座序列类型（MLST）59和葡萄球菌盒型染色体 mecA （SCC mec ）IV型。具有9个重复的直接重复单元（DRU）;是 spa 类型t437;并且易受磺胺和喹诺酮类抗生素的侵害。来自男性患者的其他六个分离株被确定与医院相关，MLST 239和SCC mec III型。有14个重复的DRU;是 spa 类型的t037;对磺胺和喹诺酮类抗生素具有抗药性。所有13种MRSA分离株均在 agr 组I中， pvl 阴性，并且没有证据表明万古霉素耐药性与自溶之间存在任何关联。

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