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首页> 外文期刊>Journal of Clinical Microbiology >Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients
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Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients

机译：乙型肝炎病毒S1前区的男性特异性W4P / R突变，增加了慢性患者肝病进展的风险

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摘要

The issue of hepatitis B virus (HBV) mutations possibly leading to a gender disparity in the progression of liver diseases has not been explored. We aimed to elucidate the relationships of the novel pre-S1 mutations, W4P/R, with the progression of liver diseases and male predominance in a South Korean chronic cohort by use of a molecular epidemiologic study. We developed a fluorescence resonance energy transfer (FRET)-based real-time PCR (RT-PCR) assay for the detection of the W4P/R mutations and applied it to 292 chronic HBV patients. The pre-S1 mutations from 247 (84.6%) of a total of 292 patients were detected by this assay. W4P/R mutants were found to be significantly related to severe liver diseases (hepatocellular carcinoma [HCC] and liver cirrhosis, 12.4% [19/153] of patients, versus chronic hepatitis and asymptomatic carriage, 1.1% [1/94] of patients) (P < 0.001). All of the W4P/R mutants were found in males only. The novel HBV pre-S1 mutations, W4P/R, may be associated with disease severity in male patients chronically infected with HBV genotype C. The W4P/R mutations may provide in part an explanation for the relatively high ratio of male to female incidence in HCC generation in South Korean chronic HBV patients.
机译：尚未探讨可能导致肝病进展中性别差异的乙型肝炎病毒（HBV）突变问题。我们旨在通过分子流行病学研究阐明新的 pre-S1 突变W4P / R与韩国慢性队列中肝病进展和男性优势的关系。我们开发了一种基于荧光共振能量转移（FRET）的实时PCR（RT-PCR）分析方法，用于检测W4P / R突变，并将其应用于292名慢性HBV患者。该方法检测了总共292名患者中的247名（占84.6％）的 pre-S1 突变。发现W4P / R突变体与严重的肝脏疾病（肝细胞癌[HCC]和肝硬化，占12.4％的患者[19/153]）显着相关，而慢性肝炎和无症状携带者则为1.1％[1/94] ）（ P <0.001）。所有W4P / R突变体仅在男性中发现。新的HBV pre-S1 突变W4P / R可能与慢性感染HBV基因型C的男性患者的疾病严重程度有关。W4P/ R突变可能在一定程度上解释了相对较高的韩国慢性HBV患者HCC发生中男女发病率的比率。

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