...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Microbiology >Antimicrobial Treatment Options for Granulomatous Mastitis Caused by Corynebacterium Species
【24h】

Antimicrobial Treatment Options for Granulomatous Mastitis Caused by Corynebacterium Species

机译：棒状杆菌引起的肉芽肿性乳腺炎的抗菌治疗选择

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Corynebacterium species are increasingly recognized as important pathogens in granulomatous mastitis. Currently, there are no published treatment protocols for Corynebacterium breast infections. This study describes antimicrobial treatment options in the context of other management strategies used for granulomatous mastitis. Corynebacterium spp. isolated from breast tissue and aspirate samples stored from 2002 to 2013 were identified and determined to the species level using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), 16S RNA sequencing, and rpoB gene targets. The MICs for 12 antimicrobials were performed using Etest for each isolate. Correlations of these with antimicrobial characteristics, choice of antimicrobial, and disease outcome were evaluated. Corynebacterium spp. from breast tissue and aspirate samples were confirmed in 17 isolates from 16 patients. Based on EUCAST breakpoints, Corynebacterium kroppenstedtii isolates (n = 11) were susceptible to seven antibiotic classes but resistant to β-lactam antibiotics. Corynebacterium tuberculostearicum isolates (n = 4) were multidrug resistant. Two nonlipophilic species were isolated, Corynebacterium glucuronolyticum and Corynebacterium freneyi, both of which have various susceptibilities to antimicrobial agents. Short-course antimicrobial therapy was common (median, 6 courses per subject; range, 1 to 9 courses). Patients with C. kroppenstedtii presented with a hot painful breast mass and underwent multiple surgical procedures (median, 4 procedures; range, 2 to 6 procedures). The management of Corynebacterium breast infections requires a multidisciplinary approach and includes culture and appropriate sensitivity testing to guide antimicrobial therapy. Established infections have a poor outcome, possibly because adequate concentrations of some drugs will be difficult to achieve in lipophilic granulomata. Lipophilic antimicrobial therapy may offer a therapeutic advantage. The role of immunotherapy has not been defined.
机译：棒状杆菌被越来越多地视为肉芽肿性乳腺炎的重要病原体。当前，没有公开的针对棒状杆菌乳房感染的治疗方案。这项研究描述了肉芽肿性乳腺炎的其他管理策略中的抗菌治疗选择。棒杆菌属使用基质辅助激光解吸电离-飞行时间质谱（MALDI-TOF MS），16S RNA测序和 rpoB < / em>基因靶标。使用Etest对每种分离物进行12种抗菌素的MIC。评估了这些因素与抗菌素特性，抗菌素选择和疾病结果的相关性。棒杆菌属在来自16例患者的17株分离物中确证了来自乳腺组织和吸出物样品的样本。根据EUCAST断点，克氏杆菌棒状分离株（ n = 11）对7种抗生素敏感，但对β-内酰胺类抗生素有抗药性。结核杆菌硬皮杆菌分离株（ n = 4）具有多重耐药性。分离了两个非亲脂性物种，解脂棒状杆菌（Corynebacterium glucuronolyticum）和费氏棒状杆菌（Corynebacterium freneyi），它们对抗菌剂均具有不同的敏感性。短程抗菌治疗很普遍（中位，每个受试者6个疗程;范围1到9个疗程）。克罗伯氏梭状芽胞杆菌患者出现热痛性乳房肿块，并接受了多次外科手术（中位，4例;范围2到6例）。棒状杆菌乳房感染的管理需要多学科的方法，包括培养和适当的敏感性测试以指导抗菌治疗。确诊的感染预后很差，可能是因为在亲脂性肉芽肿中很难获得足够浓度的某些药物。亲脂性抗菌治疗可能会提供治疗优势。免疫疗法的作用尚未确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号