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首页> 外文期刊>Journal of Clinical Microbiology >Impact of the New Abbott mPLUS Feature on Clinical Laboratory Efficiencies of Abbott RealTime Assays for Detection of HIV-1, Hepatitis C Virus, Hepatitis B Virus, Chlamydia trachomatis, and Neisseria gonorrhoeae
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Impact of the New Abbott mPLUS Feature on Clinical Laboratory Efficiencies of Abbott RealTime Assays for Detection of HIV-1, Hepatitis C Virus, Hepatitis B Virus, Chlamydia trachomatis, and Neisseria gonorrhoeae

机译：新的雅培mPLUS功能对用于检测HIV-1，丙型肝炎病毒，乙型肝炎病毒，沙眼衣原体和淋病奈瑟氏菌的雅培实时检测的临床实验室效率的影响

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Diagnostic laboratories are under increasing pressure to improve and expand their services. Greater flexibility in sample processing is a critical factor that can improve the time to results while reducing reagent waste, making laboratories more efficient and cost-effective. The introduction of the Abbott mPLUS feature, with the capacity for extended use of amplification reagents, significantly increases the flexibility of the m2000 platform and enables laboratories to customize their workflows based on sample arrival patterns. The flexibility in sample batch size offered by mPLUS enables significant reductions in processing times. For hepatitis B virus tests, a reduction in sample turnaround times of up to 30% (105 min) was observed for batches of 12 samples compared with those for batches of 24 samples; for Chlamydia trachomatis/Neisseria gonorrhoeae tests, the ability to run batches of 24 samples reduced the turnaround time by 83% (54 min) compared with that for batches of 48 samples. Excellent correlations between mPLUS and m2000 standard condition results were observed for all RealTime viral load assays evaluated in this study, with correlation r values of 0.998 for all assays tested. For the qualitative RealTime C. trachomatis/N. gonorrhoeae assay, the overall agreements between the two conditions tested were >98% for C. trachomatis and 100% for N. gonorrhoeae. Comparable precision results were observed for the two conditions tested for all RealTime assays. The enhanced mPLUS capability provides clinical laboratories with increased efficiencies to meet increasingly stringent turnaround time requirements without increased costs associated with discarding partially used amplification reagents.
机译：诊断实验室在改善和扩展服务方面面临越来越大的压力。样品处理的更大灵活性是一个关键因素，它可以缩短获得结果的时间，同时减少试剂浪费，从而使实验室更高效，更具成本效益。雅培 m PLUS功能的引入，具有扩展使用扩增试剂的能力，大大提高了 m 2000平台的灵活性，并使实验室能够根据其自定义工作流程样本到达模式。 m PLUS提供的灵活的样品批量大小可显着减少处理时间。对于乙型肝炎病毒测试，与24个样品批次相比，12个样品批次的样品周转时间最多减少了30％（105分钟）。对于沙眼衣原体/淋病奈瑟氏球菌测试，与48个样品批次相比，运行24个样品批次的能力使周转时间减少了83％（54分钟）。在本研究中评估的所有RealTi m e病毒载量测定中，观察到 m PLUS和 m 2000标准条件结果之间的极好的相关性，相关性<所有测试的em> r 值均为0.998。对于定性RealTi m e沙眼衣原体/ N。淋球菌测定法，两种测试条件之间的总体一致性对于沙眼衣原体> 98％，对于淋病奈瑟氏球菌> 100％。对于所有RealTi m e分析，在两种测试条件下均观察到了相当的精密度结果。增强的 m PLUS功能为临床实验室提供了更高的效率，可以满足日益严格的周转时间要求，而不会因丢弃部分使用的扩增试剂而增加成本。

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