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Identification of Low-Level Vancomycin Resistance in Staphylococcus aureus in the Era of Informatics

机译:信息学时代金黄色葡萄球菌对低水平万古霉素的耐药性鉴定

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Vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant VISA (hVISA) are pathogens for which accurate antimicrobial susceptibility testing (AST) would rule out standard treatment with vancomycin. Unfortunately, AST for vancomycin is relatively slow and standard methods are unable to reliably detect VISA and hVISA. An article in this issue (C. A. Mather, B. J. Werth, S. Sivagnanam, D. J. SenGupta, and S. M. Butler-Wu, J Clin Microbiol 54:883–890, 2016, doi:http://dx.doi.org/10.1128/JCM.02428-15) describes a rapid whole-cell matrix-assisted laser desorption ionization–time of flight proxy susceptibility method that highlights current innovations and challenges with rapid AST, VISA/hVISA identification, and clinical bioinformatics.
机译:万古霉素中间型金黄色葡萄球菌(VISA)和耐异性VISA(hVISA)是病原体,对于这些病原体,准确的抗菌药敏试验(AST)会排除万古霉素的标准治疗方法。不幸的是,万古霉素的AST相对较慢,并且标准方法无法可靠地检测VISA和hVISA。本期文章(CA Mather,BJ Werth,S.Sivagnanam,DJ SenGupta和SM Butler-Wu,J Clin Microbiol 54:883–890,2016,doi:http://dx.doi.org/10.1128/ JCM.02428-15)描述了一种快速的全细胞基质辅助激光解吸电离飞行时间代理药敏方法,重点介绍了快速AST,VISA / hVISA鉴定和临床生物信息学方面的当前创新和挑战。

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