Drug prescribing is the most essential practice of medical professionals. A single drug to be marketed has to undergo rigorous processes and drug trials before it is labelled as safe for use in humans. However, all the adverse effects and toxicities cannot be elicited in the limited number of volunteers used in the phased trial. A lot of dangerous rare toxicities come to light only when drugs are marketed and prescribed to thousands of people. Drug regulatory bodies should be aware of these facts and take prompt initiatives to withdraw their sale. Similarly useless and irrational combinations flow the markets without any additional benefits to the patient. This review is an attempt to create awareness about drugs that are no longer used due to lack of safety, those once banned but reintroduced, those that are still used despite toxicities and doubtful efficacy and drugs surrounded by controversies.
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