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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prevalence of High and Low Level Mupirocin Resistance among Staphylococcal Isolates from Skin Infection in a Tertiary Care Hospital
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Prevalence of High and Low Level Mupirocin Resistance among Staphylococcal Isolates from Skin Infection in a Tertiary Care Hospital

机译：三级护理医院皮肤感染葡萄球菌分离株对莫匹罗星耐药的高低水平

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Background:Mupirocin has been used for the treatment ofskin infections and for the eradication of the nasal carriage of Methicillin -resistant Staphylococcus aureus(MRSA). The increased use of this antibiotic has been accompanied by its resistance, resulting in treatment failures. Objective:This study was aimed at determining the prevalences of low and high level Mupirocin resistance among the clinical isolates of Staphylococcus species which were obtained from pyogenic infections.Material and Method:Clinical samples such as wound swabs,tissues and pus which were submitted to the microbiology laboratory during a period of six months were screened for the growth of Staphylococcus species, which were identified as Staphylococcus aureus and Coagulase negative Staphylococcus species by the routine microbiological procedures. All the isolates were tested for their Mupirocin susceptibilities by using 5 and 200 μg discs and their resistance was confirmed from their Minimum Inhibitory Concentrations (MICs). Result:Out of 400 samples, 150 samples grew Staphylococcus species,of which 113 wereStaphylococcus aureus and 37 were Coagulase negative Staphylococcus(CoNS). Only 5(3.3%)mupirocin resistant Staphylococcus species: three high level and two low level strains were detected. The MICs for the two low level and three high level Mupirocin resistant strains were 256mg/L and= 512mg/L each respectively.Conclusion:We conclude that the screening for mupirocin resistance, in terms of high-level and low-level resistance among theStaphylococcus species from patients with skin and soft tissue infections is warranted and that it is important for the clinicians in selecting the appropriate, empirical, topical,antimicrobial therapy. It also provides useful information about the prevalence of these resistant pathogens.
机译：背景：莫匹罗星已用于治疗皮肤感染和根除耐甲氧西林金黄色葡萄球菌（MRSA）的鼻腔运输。这种抗生素的增加使用伴随有其抗药性，导致治疗失败。目的：本研究旨在确定化脓性感染获得的葡萄球菌临床分离株中低水平和高水平的莫匹罗星耐药的发生率。材料与方法：将临床样本如伤口拭子，组织和脓液提交给微生物实验室在六个月的时间内对葡萄球菌的生长情况进行了筛选，通过常规的微生物学程序将其鉴定为金黄色葡萄球菌和凝固酶阴性葡萄球菌。通过使用5和200μg圆盘测试所有分离物的莫匹罗星敏感性，并通过其最小抑菌浓度（MIC）确认其耐药性。结果：在400份样本中，生长了150种葡萄球菌，其中金黄色葡萄球菌113种，凝固酶阴性葡萄球菌（CoNS）37种。仅检测到5种（3.3％）对莫匹罗星耐药的葡萄球菌：三种高水平菌株和两种低水平菌株。两个低水平和三个高水平对Mupirocin耐药菌株的MIC分别为256mg / L和= 512mg / L。结论：我们得出结论，从葡萄球菌的高水平和低水平耐药性方面筛选了莫匹罗星耐药性有皮肤和软组织感染的患者应该选择这种细菌，并且对于临床医生选择适当的，经验的，局部的抗微生物治疗非常重要。它还提供了有关这些耐药病原体流行情况的有用信息。

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