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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Diagnostic Utility of HeatStable Alkaline Phosphatase in Hypertensive Disorders of Pregnancy
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Diagnostic Utility of HeatStable Alkaline Phosphatase in Hypertensive Disorders of Pregnancy

机译：热稳定碱性磷酸酶在妊娠高血压疾病中的诊断作用

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Background: Hypertensive disorders in pregnancy (HDP) complicate 3-10% of all pregnancies. Though there are several biochemical parameters which aid in predicting hypertension of pregnancy, human placental alkaline phosphatase (PLAP), synthesized in placenta during pregnancy by placental syncytiotrophoblast, assumes diagnostic relevance. The purpose of this study was to compare the total alkaline phosphatase (ALP) and heat stable placental alkaline phosphatase (PLAP) levels in the serum of normotensive and hypertensive disorders of pregnancy and to evaluate the clinical utility of ALP and PLAP as a reliable, sensitive, specific and economical biochemical marker of HDP.Materials and Methods: This was a case control study, carried out on pregnant women with hypertension, of south Indian population. Study included pregnant women, 60 patients with hypertension and 60 controls. Biochemical assays were carried out by the IFCC approved procedures based on spectrophotometric method and using fully automated random access chemistry analyser. Data was compared by using student t-test. ROC was drawn to find out optimum cut off for ALP, PLAP and PLAP/ALP ratio in HDP. Pearson?s correlation was performed to ascertain the association among markers.Results: Serum total ALP, PLAP and PLAP/ALP ratio levels were significantly higher in hypertensive pregnant women when compared to controls (p<0.05). There was significant correlation among ALP, PLAP and DBP. ROC analysis of ALP (169.5), PLAP (69) and PLAP/ALP (0.44) ratios showed optimum cut-offs in diagnosis of hypertension in pregnancy.Conclusion: Serum heat stable ALP isoenzyme and PLAP/ALP ratio could be useful adjuvant markers in diagnosis of HDP in association with other relevant and economically viable biochemical tests.
机译：背景：妊娠高血压疾病（HDP）使所有怀孕的3-10％复杂化。尽管有一些生化参数有助于预测妊娠高血压，但是在妊娠期间胎盘合体滋养层细胞在胎盘中合成的人胎盘碱性磷酸酶（PLAP）仍具有诊断意义。这项研究的目的是比较妊娠正常血压和高血压疾病血清中的总碱性磷酸酶（ALP）和热稳定的胎盘碱性磷酸酶（PLAP）水平，并评估ALP和PLAP作为可靠，敏感的临床用途，是HDP的特定且经济的生化指标。材料与方法：这是一项病例对照研究，针对印度南部印度裔的高血压孕妇。研究包括孕妇，60名高血压患者和60名对照。生化分析是通过IFCC批准的分光光度法并使用全自动随机存取化学分析仪进行的。使用学生t检验比较数据。绘制ROC以找出HDP中ALP，PLAP和PLAP / ALP比的最佳截止值。结果显示：与对照组相比，高血压孕妇的血清总ALP，PLAP和PLAP / ALP比率水平显着更高（p <0.05）。 ALP，PLAP和DBP之间存在显着相关性。 ROC分析ALP（169.5），PLAP（69）和PLAP / ALP（0.44）比率显示了诊断妊娠高血压的最佳临界值。结论：血清热稳定ALP同工酶和PLAP / ALP比率可能是有用的辅助标记物HDP的诊断以及其他相关的和经济上可行的生化检测。

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