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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Increased Serum Alkaline Phosphatase and Serum Phosphate as Predictors of Mortality after Stroke
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Increased Serum Alkaline Phosphatase and Serum Phosphate as Predictors of Mortality after Stroke

机译：血清碱性磷酸酶和血清磷酸水平升高是卒中后死亡率的预测因子

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Context: Serum Alkaline phosphatase (ALP) & phosphate are considered to be indicators of vascular calcification. Link between bone metabolism, vascular calcification, cardiovascular events have been well studied in chronic kidney disease and ischemic heart disease.Aims: To determine that increased serum phosphate and alkaline phosphatase are predictors of mortality rates and recurrent vascular events in stroke.Materials and Methods: Sixty patients admitted with acute stroke (ischemic & haemorrhagic) were included in the study. Their baseline clinical characteristics and biochemical parameters including serum ALP and phosphate were noted. All patients were followed up for a period of one year. The all- cause mortality, the mortality due to cardiovascular events and recurrent vascular events without death were noted during the follow up. Statistical analyses were done to look for any correlation between mortality and baseline levels of serum ALP and phosphate.Results:Of the 60 patients, 8 (13.3%) patients were lost for follow up. Fourteen (26.9%) patients died; of which 12 deaths were due to vascular causes and 2 deaths were due to non vascular causes. Increasing levels of serum ALP and phosphate correlated with all cause mortality and recurrent vascular events without death.Conclusion:Serum ALP and phosphate prove to be cost effective prognostic indicator of mortality and recurrent vascular events in stroke. This finding has to be confirmed with studies including larger population. Further research on ALP inhibitors, Vitamin D analogues and phosphate binders to improve mortality in stroke population can be encouraged.
机译：背景：血清碱性磷酸酶（ALP）和磷酸盐被认为是血管钙化的指标。在慢性肾脏病和局部缺血性心脏病中，骨代谢，血管钙化，心血管事件之间的联系已得到很好的研究。目的：确定血清磷酸盐和碱性磷酸酶升高是卒中死亡率和复发性血管事件的预测指标。材料和方法：纳入研究的60名急性中风（缺血性和出血性）患者。记录了他们的基线临床特征和生化参数，包括血清ALP和磷酸盐。所有患者均接受了为期一年的随访。在随访中记录了全因死亡率，心血管事件导致的死亡率和无死亡的反复血管事件。进行统计分析以寻找死亡率与血清ALP和磷酸盐基线水平之间的任何相关性。结果：60例患者中，有8例（13.3％）失访。 14例（26.9％）患者死亡;其中12例死亡是由血管原因引起的，2例死亡是由于非血管原因引起的。血清ALP和磷酸盐水平升高与所有致死因素和复发性血管事件相关，而无死亡。结论：血清ALP和磷酸盐被证明是卒中死亡率和复发性血管事件的经济有效的预后指标。这一发现必须通过包括更多人群在内的研究得到证实。可以鼓励进一步研究ALP抑制剂，维生素D类似物和磷酸盐结合剂以改善卒中人群的死亡率。

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