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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Patients? Adherence and Adverse Drug Reactions (ADRs) which are Caused by Helicobacter Pylori Eradication Regimens
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The Patients? Adherence and Adverse Drug Reactions (ADRs) which are Caused by Helicobacter Pylori Eradication Regimens

机译：患者？幽门螺杆菌根除方案引起的粘附和药物不良反应（ADR）

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Background: Helicobacter pylori is a major cause of upper gastrointestinal disorders. The eradication of H. pylori has been recommended for the treatment of different gastrointestinal diseases. Notwithstanding, a combination therapy is needed for Helicobacter pylori eradication, but using these medications can be the cause, the incidence risk of patients? adherence to treatment regimens reduction and probably increase risk of Adverse Drug Reactions (ADRS), so, it is seem that evaluation the out come of combination therapy is need more than the past.Aim: The aim of present study was to determine the patients? adherence to the treatment and the ADRs with five eradiation regimens.Setting and Design: A cross sectional study was done in a well known referral clinic of gastrointestinal disorders in Tehran, Iran.Methods and Materials: 90 patients were evaluated the study (18 in each of the five regimens). The adherence to the treatment and the ADRs of the patients were asked during the treatment, twice, by doing telephone assays.Statistical Analysis Used: The data were analyzed by using the SPSS, 17 software and the statistical significance was accepted for the P values of 0.05.Results: 81% of the patients had a good adherence and there was no significant difference between the types of regimens (triple or quadruple therapy) and the adherence to the treatment regimens by the patients (p=0.6). Also, we found that there was no significant relationship between the types of regimens and the sex (p=0.99), education level (p=0.99), accommodation (p=0.93), an existence of underlying disease (p=0.86) and the concurrent use other medications (p=0.93). But there was a significant relationship between the patients? age and adherence to the treatment regimens (p=0.008). The most reported ADRs belonged to gastrointestinal (GI) disorders (an abnormal taste had the most prevalence (36.6%) among the GI disorders). There was no significant relationship between the regimen type and the GI ADRs, (p=0.48).Conclusion: The findings of this study showed that the patients? adherence to the treatment regimens and the ADRs did not have a significant relationship with the various eradication regimens for H.pylori. It seems that the type of H. pylori eradication regimen may not be an important factor in the patients? adherence to the treatment regimens and the ADRs.
机译：背景：幽门螺杆菌是上消化道疾病的主要原因。根除幽门螺杆菌已被推荐用于治疗各种胃肠道疾病。尽管如此，根除幽门螺杆菌仍需要联合治疗，但使用这些药物可能是引起患者发病风险的原因吗？坚持减少治疗方案并可能增加药物不良反应（ADRS）的风险，因此，似乎比以往更需要评估联合治疗的结果。目的：本研究的目的是确定患者？坚持治疗和五种放疗方案的ADR设置与设计：在伊朗德黑兰的一家著名的胃肠道疾病转诊诊所进行了横断面研究。方法与材料：对90名患者进行了研究评估（每人18名）五种方案中的一种）。在治疗过程中，通过电话分析两次询问患者对治疗的依从性和ADR。使用统计分析：使用SPSS，17软件分析数据，并接受P值的统计显着性0.05。结果：81％的患者具有良好的依从性，方案类型（三重或四联疗法）与患者对治疗方案的依从性之间无显着差异（p = 0.6）。此外，我们发现治疗方案的类型与性别（p = 0.99），受教育程度（p = 0.99），住宿（p = 0.93），潜在疾病的存在（p = 0.86）和性别之间无显着关系。同时使用其他药物（p = 0.93）。但是患者之间有重要关系吗？年龄和对治疗方案的依从性（p = 0.008）。报道最多的ADR属于胃肠道（GI）疾病（在GI疾病中，异味的发生率最高（36.6％））。方案类型与胃肠道不良反应之间无显着相关性，（p = 0.48）。结论：本研究的结果表明，患者？坚持治疗方案和ADR与幽门螺杆菌的各种根除方案没有显着关系。根除幽门螺杆菌的方案似乎不是患者的重要因素？遵守治疗方案和ADR。

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