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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis
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Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis

机译：阿奇霉素作为牙周炎非手术牙周治疗的辅助疗法的疗效：系统评价和荟萃分析

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Introduction: Over the years, numerous trials have sufficiently documented benefits of adjuvant administration of antibiotics in combination to Scaling and Root Planing (SRP) in treatment of periodontitis. Nevertheless there are justified doubts in respect to antibiotics administration with regard to increasing development of resistances.Aim: The aim of this review study and meta-analysis was to verify a possible benefit of Azithromycin (AZM) as an alternative adjuvant antibiotic in combination with SRP.Materials and Methods: Electronic databases (Pubmed) were searched from the earliest point of record until May 2015. A hand search was also conducted. The variables considered in this respect were Probing Depth (PD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and SRP. A meta-analysis containing trials comparing SRP as a sole therapy with SRP and administration of AZM was produced once all of the data obtained had been reviewed.Results: Six randomised clinical trials were accepted into the review and the meta-analysis following the process of trial selection. Meta-analysis revealed larger overall effects by the systemic administration of AZM compared with SRP on their own in terms of PD, CAL, BOP, Plaque-Index and total bacterial load reduction after three and six months.Conclusion: The data used in this study revealed that the systemic administration of AZM is beneficial compared with SRP on its own for the treatment of chronic periodontitis
机译：简介：多年来，许多试验已充分记录了佐剂联合根皮平整和根部平整（SRP）辅助治疗牙周炎的益处。然而，关于增加耐药性发展方面的抗生素给药仍存在合理的怀疑。目的：本综述研究和荟萃分析的目的是验证阿奇霉素（AZM）作为替代佐剂抗生素与SRP联合使用的可能益处。 。材料与方法：从最早的记录开始直到2015年5月，都检索了电子数据库（已公开），并进行了手工检索。在这方面考虑的变量是探查深度（PD），临床依从水平（CAL），探查出血（BOP）和SRP。一旦对所有获得的数据进行了回顾，就进行了荟萃分析，其中包含比较SRP作为SRP单独治疗和AZM给药的试验的结果。结果：六项随机临床试验被纳入该综述，并按照以下步骤进行了荟萃分析。试用选择。荟萃分析显示，与单独使用SRP相比，AZM全身性给药在PD，CAL，BOP，菌斑指数和三个月和六个月后总细菌负荷减少方面具有更大的总体效果。结论：本研究中使用的数据揭示了与单独使用SRP相比，AZM的全身给药对治疗慢性牙周炎是有益的

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