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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Speciation and Antimicrobial Susceptibility pattern of Enterococci from a Tertiary Health Care Center in North India.
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Speciation and Antimicrobial Susceptibility pattern of Enterococci from a Tertiary Health Care Center in North India.

机译：来自印度北部第三级卫生保健中心的肠球菌的形态和抗菌药敏模式。

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Introduction: In recent years, Enterococci have become important nosocomial pathogens. Therefore, it is important for a hospital setting to continuously monitor such infections, and to determine their species and antimicrobial susceptibility pattern from time to time. Keeping these objectives in mind, the present study was conducted in our tertiary health care center in North India. Methods: A total of 100 enterococcal strains isolated from urine and blood samples were speciated as per the scheme of Facklam and Collins. Antibiotic susceptibility was determined for Amoxycillin, Penicillin, Cephalexin, Erythromycin, Cotrimoxazole, Gentamicin, Vancomycin, Teicoplanin, Linezolid, Imipenem, Piperacillin, Ampicillin- sulbactam, and Nitrofurantoin by the Kirby Bauer disc diffusion method. MIC detection was done by the agar dilution method for penicillin and vancomycin. HLAR detection was done by the agar dilution method for gentamicin and streptomycin, by supplementing the Mueller Hinton agar with 500μg/ml and 2000 μg/ml of the antibiotics, respectively. Results: 96 of the strains were of Enterococcus faecalis, and 4 were of Enterococcus faecium. Antibiotic susceptibility tests showed a high level of resistance to cephalexin (100%), gentamicin(96.42%), cotrimoxazole (87.03%), erythromycin (77.19%), and penicillin (61.17%). However, only two strains were found to be resistant to vancomycin and teicoplanin. All the strains were sensitive to linezolid. HLAR was seen in 75% of the strains for gentamicin, and in 69% strains for streptomycin. In case of penicillin, MIC values were found to be >16 μg/ml for 14 strains (14%). 6 strains had MIC values of upto 4μg/ml for vancomycin. Out of these, one E. faecalis strain turned out to be Vancomycin resistant enterococci (VRE) showing an MIC value as high as 512 μg/ml.Conclusion: We conclude that enterococcal strains with high rate of resistance to penicillin and aminoglycosides are prevalent in our nosocomial setting, and emergence of the VRE strain has further worsened this situation. There is an urgent need for more rational and restricted use of antimicrobials in order to minimize the selection and spread of such strains.
机译：简介：近年来，肠球菌已成为重要的医院病原体。因此，对于医院机构而言，连续监测此类感染并不时确定其种类和抗菌药性模式非常重要。牢记这些目标，本研究是在我们位于北印度的三级医疗中心进行的。方法：按照Facklam和Collins的方案，从尿液和血液样本中分离出总共100株肠球菌。通过Kirby Bauer纸片扩散法测定了阿莫西林，青霉素，头孢氨苄，红霉素，复方新唑，庆大霉素，万古霉素，替考拉宁，利奈唑胺，亚胺培南，哌拉西林，氨苄青霉素，舒巴坦和呋喃妥因的抗生素敏感性。通过青霉素和万古霉素的琼脂稀释法进行MIC检测。通过琼脂稀释法对庆大霉素和链霉素进行HLAR检测，分别向Mueller Hinton琼脂补充500μg/ ml和2000μg/ ml的抗生素。结果：96株为粪肠球菌，4株为粪肠球菌。抗生素药敏试验显示，对头孢氨苄（100％），庆大霉素（96.42％），科曲唑（87.03％），红霉素（77.19％）和青霉素（61.17％）的耐药性较高。然而，仅发现两个菌株对万古霉素和替考拉宁具有抗性。所有菌株均对利奈唑胺敏感。在庆大霉素的菌株中有75％出现HLAR，链霉素的菌株中有69％出现HLAR。对于青霉素，发现14株（14％）的MIC值> 16μg/ ml。 6株万古霉素的MIC值高达4μg/ ml。其中，一株粪肠球菌被证明是耐万古霉素的肠球菌（VRE），其MIC值高达512μg/ ml。结论：我们得出结论，肠球菌菌株对青霉素和氨基糖苷的耐药率很高。我们的医院环境以及VRE株的出现进一步加剧了这种情况。迫切需要更合理，更严格地使用抗菌剂，以最大程度地减少此类菌株的选择和传播。

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