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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Serum Selenium Level in PatientsWith Uncomplicated Diabetes Mellitus, Raipur, India
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Evaluation of Serum Selenium Level in PatientsWith Uncomplicated Diabetes Mellitus, Raipur, India

机译:单纯性糖尿病患者血清硒水平的评估,印度赖布尔

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Objective-Free radicals have important role in the pathogenesis of diabetes mellitus. In diabetes, free radical production is increased whereas capacity of antioxidant system is reduced. This study was, therefore designed to determine and evaluate the serum selenium level in patient with uncomplicated diabetes mellitus and a control group of non-diabetic individuals. Study design- Hospital based non randomized, multistage, stratified, cross-sectional comparative study. Material and Method- 50 uncomplicated diabetic patients (23 male, 27 female) with mean age of 49.10±6.48 years were enrolled in the study. Control group was composed of 50 healthy individual (22 male, 28 female) with mean age of 52.74 ±7.5 years. Serum selenium level was determined by using Hydride generation atomic absorption spectrometry in diabetic patients and controls. Result ? Mean serum- selenium concentration measured in uncomplicated diabetic patients (51.9±8.23 μg/lit) were significantly lower than those determined in control group (130.66±37.18 μg/lit) (p 0.05). Conclusion- The result of this comparative evaluation confirms the relation between low serum selenium and diabetes. Significant reduction in selenium levels are indicators of metabolic response to oxidative stress in patient with diabetes. Hence, selenium can be used in diabetic patient to prevent the late complications. The present study indicates that since it is a hospital based study, the same study should be conducted in general population (community based) to further evaluate the effect of serum-selenium in diabetes.
机译:客观自由基在糖尿病的发病机理中具有重要作用。在糖尿病中,自由基产生增加,而抗氧化系统的能力降低。因此,本研究旨在确定和评估单纯糖尿病患者和非糖尿病患者对照组的血清硒水平。研究设计-基于医院的非随机,多阶段,分层,横断面比较研究。材料和方法-研究纳入了50例平均年龄为49.10±6.48岁的糖尿病并发症患者(男23例,女27例)。对照组由50名健康个体(22名男性,28名女性)组成,平均年龄为52.74±7.5岁。通过使用氢化物​​发生原子吸收光谱法测定糖尿病患者和对照组的血清硒水平。结果呢?在简单糖尿病患者中测得的平均血清硒浓度(51.9±8.23μg/ lit)显着低于对照组(130.66±37.18μg/ lit)(p 0.05)。结论:该比较评估的结果证实了血清硒水平低与糖尿病之间的关系。硒水平的显着降低是糖尿病患者对氧化应激代谢反应的指标。因此,硒可用于糖尿病患者以预防晚期并发症。本研究表明,由于这是基于医院的研究,因此应在普通人群(基于社区)中进行相同的研究,以进一步评估血清硒在糖尿病中的作用。

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