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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Vigabatrin induced Cell loss in the Cerebellar Cortex of Albino Rats
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Vigabatrin induced Cell loss in the Cerebellar Cortex of Albino Rats

机译：Vigabatrin诱导白化大鼠小脑皮质细胞丢失

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Background: Vigabatrin (an antiepileptic drug) is used as the drug of choice in resistant epilepsy and infantile spasms. Ataxia, tremors and abnormal gait have been frequently reported following the use of this drug, indicating an involvement of the cerebellum. Objectives: The present study was designed to study the histopathological effects of Vigabatrin on the cerebellum of albino rats. Material and Methods: Rats were divided into an experimental and a control group. Vigabatrin was administered intra?peritoneally to the experimental group in graded doses for a period of 4 weeks. At the end of the treatment period, rats were sacrificed and brains were dissected out. The cerebellum was separated and fixed. Slides were prepared for histological examination.Results: Decreased cell counts in the cerebellar cortex secondary to toxic injury were found. Severity increased with increasing doses.Interpretation and conclusion: Vigabatrin may be neurotoxic and should be used with caution, assessing cerebellar function at regular intervals.
机译：背景：Vigabatrin（抗癫痫药）被用作抗药性癫痫和婴儿痉挛症的首选药物。使用该药后，经常出现共济失调，震颤和步态异常，表明小脑受累。目的：本研究旨在研究Vigabatrin对白化病大鼠小脑的组织病理学影响。材料和方法：将大鼠分为实验组和对照组。 Vigabatrin经腹膜内给予分级剂量的实验组，持续4周。在治疗期结束时，处死大鼠并解剖脑。小脑被分离并固定。结果：发现中毒后小脑皮层细胞计数减少。严重程度随剂量增加而增加。解释和结论：Vigabatrin可能具有神经毒性，应谨慎使用，并定期评估小脑功能。

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