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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of 25(OH) Vitamin D3 with Reference to Mmagnesium Statusand Insulin Resistance in T2DM
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Evaluation of 25(OH) Vitamin D3 with Reference to Mmagnesium Statusand Insulin Resistance in T2DM

机译：参照镁状态和2型糖尿病患者胰岛素抵抗评估25（OH）维生素D3

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Introduction: Calcium is a recognized second messenger implicated in insulin secretion. Vitamin D (1,25-dihydroxycholecalciferol, Calcitriol) plays a role in calcium metabolism. This explains the indirect role of Vitamin D in insulin secretion and insulin sensitivity. Hence, low Vitamin D levels are implicated in decreased insulin secretion and increased insulin resistance. In this study, we tried to find out the probable association of Vitamin D3, calcium and magnesium with reference to insulin resistance in type 2 diabetes mellitus (T2DM) cases. It is well documented that measurement of circulating 25-Hydroxycholecalciferol {25 (OH)Vitamin D3} is a marker of total Vitamin D status.Methodology: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls. We estimated Vitamin D status, calcium and magnesium levels in the light of insulin resistance. Insulin resistance was measured by homeostasis model assessment of insulin resistance (HOMA-IR).Results: Twenty five (OH) Vitamin-D3 level was significantly low among T2DM cases (12.29+2.32ng/ml) in comparison to healthy controls (19.55+0.50ng/ml) (p<0.01). The levels of calcium and magnesium were also significantly low in T2DM cases as compared to healthy controls (p<0.01). There was significant negative correlation between Vitamin D status and insulin levels, and insulin resistance (p<0.01).Implication: A significant negative correlation between Vitamin D status and insulin levels suggest that the supplementation of Vitamin D has the potential to increase insulin sensitivity and lower the risk of developing type 2 diabetes mellitus.
机译：简介：钙是公认的与胰岛素分泌有关的第二信使。维生素D（1,25-二羟基胆钙化固醇，骨化三醇）在钙代谢中起作用。这解释了维生素D在胰岛素分泌和胰岛素敏感性中的间接作用。因此，低维生素D水平与胰岛素分泌减少和胰岛素抵抗增加有关。在这项研究中，我们试图找出2型糖尿病（T2DM）病例中维生素D3，钙和镁与胰岛素抵抗的可能关联。众所周知，循环中的25-羟胆钙化固醇{25（OH）维生素D3}的测量是总维生素D状况的标志。方法：我们在30位年龄和性别相匹配的30岁T2DM受试者中测量了25（OH）维生素D3水平。控制。根据胰岛素抵抗，我们估算了维生素D的状态，钙和镁的水平。通过对胰岛素抵抗的稳态模型评估（HOMA-IR）来测量胰岛素抵抗。结果：与健康对照组（19.55+）相比，T2DM患者中的25（OH）维生素D3水平显着较低（12.29 + 2.32ng / ml）。 0.50ng / ml）（p <0.01）。与健康对照组相比，T2DM病例中的钙和镁含量也显着较低（p <0.01）。维生素D状况与胰岛素水平和胰岛素抵抗之间存在显着的负相关（p <0.01）。含义：维生素D状况与胰岛素水平之间存在显着的负相关关系，表明补充维生素D有可能增加胰岛素敏感性和降低罹患2型糖尿病的风险。

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