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首页> 外文期刊>Journal of Clinical and Diagnostic Research >C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review
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C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review

机译：C反应蛋白（CRP）及其与牙周疾病的关系：简要综述

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摘要

Periodontal disease is a chronic infection of the gums characterised by a loss of attachment between the tooth and bone, and bone loss. C-reactive protein (CRP) elevation is a part of the acute phase response to acute and chronic inflammation. Many epidemiological studies have shown that serum CRP levels were elevated in patients with chronic periodontitis. CRP levels increase to hundreds of μg/ml within hours following infection. It out-performs erythrocyte sedimentation rate (ESR) in terms of responsiveness and specificity for inflammation. While CRP elevation is suggestive of inflammation or infection in the appropriate clinical context, it can also occur with obesity and renal dysfunction. Conversely, a lack of CRP elevation in inflammation may be seen with hepatic failure, as well as during flares of conditions such as systemic lupus erythematosus.
机译：牙周疾病是牙龈的慢性感染，其特征是牙齿和骨骼之间的附着力丧失以及骨质流失。 C反应蛋白（CRP）升高是急性和慢性炎症急性期反应的一部分。许多流行病学研究表明，慢性牙周炎患者的血清CRP水平升高。感染后数小时内CRP水平增加至数百μg/ ml。就炎症反应和特异性而言，它的表现优于红细胞沉降率（ESR）。虽然CRP升高在适当的临床背景下提示炎症或感染，但肥胖和肾功能不全也可能发生。相反，在肝功能衰竭以及诸如全身性红斑狼疮等疾病发作期间，炎症中缺乏CRP升高。

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