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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of In-vitro Activities of Linezolid and Vancomycin against Staphylococcus aureus Isolated from A Tertiary Care Hospital
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Comparison of In-vitro Activities of Linezolid and Vancomycin against Staphylococcus aureus Isolated from A Tertiary Care Hospital

机译：利奈唑胺和万古霉素对三级医院分离的金黄色葡萄球菌体外活性的比较

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Background:Methicillin resistant Staphylococcus aureus (MRSA) has emerged as one of the commonest cause of hospital acquired infections worldwide. Vancomycin is the antibiotic of choice for treatment of MRSA, but due to slow increase in vancomycin minimum inhibitory concentration (MIC) (vancomycin creep),Vancomycin has become a suboptimal therapeutic option in critically ill patients. Linezolid has emerged as an alternative drug in the treatment of such cases.Aim:To compare in vitro activities of linezolid and vancomycin against Staphylococcus aureus , in order to help in formulating a better treatment.Method:200 strains of Staphylococcus aureus were isolated from different clinical specimens between April 2010 to March 2011. Antibiotic sensitivity testing was performed by Kirby Bauer disc diffusion method and MICs of vancomycin and linezolid were determined for all 200 strains by agar dilution method by following CLSI guidelines.Results:Among 200 strains, MIC for linezolid was 4 μg/ml for 3 strains, MIC was 2 μg/ml for 71 strains, and MIC was 1 μg/ml for 126 strains, while for the same 200 strains of Staphylococcus aureus , MIC of vancomycin was 4 μg/ml for 8 strains, it was 2 μg/ ml for 103 strains and it was 1 μg/ml for 89 strains.Conclusion:Linezolid and vancomycin had similar in-vitro efficacies for Staphylococcus aureus in disc diffusion method, but the number of strains with higher ranges of MICs of vancomycin (1-4 μg/ml) were more as compared to those which had higher ranges of MICs for linezolid. So, we suggest that linezolid can be a good alternative for the treatment of multidrug resistant Staphylococcus aureus as compared to vancomycin.
机译：背景：耐甲氧西林的金黄色葡萄球菌（MRSA）已成为全球医院获得性感染的最常见原因之一。万古霉素是治疗MRSA的首选抗生素，但由于万古霉素最低抑菌浓度（MIC）缓慢增加（万古霉素蠕变），万古霉素已成为危重患者的次佳治疗选择。目的：比较利奈唑胺和万古霉素对金黄色葡萄球菌的体外活性，以帮助制定更好的治疗方法。方法：从不同菌株中分离出200株金黄色葡萄球菌。临床标本于2010年4月至2011年3月之间进行。采用Kirby Bauer纸片扩散法进行抗生素敏感性测试，并按照CLSI指南通过琼脂稀释法测定所有200株万古霉素和利奈唑胺的MIC。 3株为4μg/ ml，71株MIC为2μg/ ml，126株MIC为1μg/ ml，同样200株金黄色葡萄球菌，万古霉素的MIC为4μg/ ml菌株：103株为2μg/ ml，89株为1μg/ ml。结论：利奈唑胺和万古霉素在圆盘扩散法中对金黄色葡萄球菌具有相似的体外功效，但数量万古霉素MIC范围较高的菌株（1-4μg/ ml）比利奈唑胺MIC范围较高的菌株更多。因此，与万古霉素相比，我们建议利奈唑胺可以作为治疗多药耐药的金黄色葡萄球菌的好选择。

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