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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Candida tropicalis as a Predominant Isolate from Clinical Specimens and its Antifungal Susceptibility Pattern in a Tertiary Care Hospital in Southern India
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Candida tropicalis as a Predominant Isolate from Clinical Specimens and its Antifungal Susceptibility Pattern in a Tertiary Care Hospital in Southern India

机译：热带假丝酵母作为临床标本的主要分离物及其在印度南部三级医院的抗真菌药性模式

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Background: The incidence of infections caused by Candida species has increased considerably over the past three decades mainly due to the rise of the AIDS epidemic, an increasingly aged population, higher numbers of immunocompromised patients and the more widespread use of indwelling medical devices. Candida tropicalis is emerging pathogenic yeast among non-albicans species. Recently drug-resistant C.tropicalis was also reported in hospitals. Aim and Objective: The present study aimed to isolate and speciate C. tropicalis from various clinical samples and to determine its antifungal susceptibility profile. Materials and Methods: Clinical samples such as urine, blood, exudates and vaginal swab which were submitted to the Microbiology laboratory during the year 2013 were screened for the growth of Candidia species, which then identified as C.tropicalis by the routine microbiological procedures such as germ tube formation, assimilation and fermentation of sugars and colony color on HICHROM Candida agar. Antifungal susceptibility was performed by disc diffusion method with the drugs Amphotericin-B, Itraconazole, Ketaconazole and Fluconazole on C. tropicalis isolates. Results: A total number of 112 Candida isolates were isolated during the year 2012 from various clinical specimens. Among them 61 (54.3%) were identified as C.tropicalis. All the C. tropicalis isolates were sensitive to Amphotericin-B (100%) but 23 isolates (37.7%) were resistant to Fluconazole. Conclusion: We conclude that identification of Candida species is important to know the prevalent species in the clinical setup and routine antifungal susceptibility should be performed to avoid inappropriate treatment.
机译：背景：在过去的三十年中，念珠菌引起的感染率显着增加，这主要是由于艾滋病流行，人口老龄化，免疫功能低下的病人数量增加以及留置医疗设备的广泛使用。热带假丝酵母是非白色念珠菌中的新兴致病酵母。最近在医院中也报告了耐药的C.tropicalis。目的和目的：本研究旨在从各种临床样品中分离和鉴定热带念珠菌，并确定其抗真菌药性。材料和方法：筛查2013年提交微生物学实验室的尿液，血液，渗出液和阴道拭子等临床样品中念珠菌的生长情况，然后通过常规微生物程序将其鉴定为C.tropicalis。 HICHROM念珠菌琼脂上的胚芽管形成，糖和菌落颜色的同化和发酵。通过圆盘扩散法用两性霉素B，伊曲康唑，Ketaconazole和氟康唑对热带假单胞菌进行药敏试验。结果：2012年期间，从各种临床标本中共分离出112株念珠菌。其中61例（54.3％）被鉴定为热带梭菌。所有热带念珠菌分离株均对两性霉素B敏感（100％），但23个分离株（37.7％）对氟康唑耐药。结论：我们的结论是，鉴定念珠菌属物种对于了解临床设置中的流行物种很重要，因此应进行常规抗真菌药性以避免不适当的治疗。

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