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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinicopathological Study of Eosinophilic Cholecystitis: Five Year Single Institution Experience EC20-EC23
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Clinicopathological Study of Eosinophilic Cholecystitis: Five Year Single Institution Experience EC20-EC23

机译：嗜酸性胆囊炎的临床病理研究：五年单一机构经验EC20-EC23

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Introduction: Gallbladder diseases are very common in Northern India, most common of which is Chronic Cholecystitis. Rarely, histopathological diagnosis of Eosinophilic Cholecystitis (EC) is given when transmural cellular infiltrate consists of more than 90% eosinophils. Aim: To determine the prevalence and clinicopathological profile of eosinophilic cholecystitis at a tertiary care hospital of New Delhi. Materials and Methods: This was a retrospective clinicopathological study done on twenty two cases of eosinophilic cholecystitis over a period of five years from January 2011- December 2015. In cases diagnosed histopathologically as eosinophilic cholecystitis, clinical details were obtained from hospital records and slides were retrieved. Various histologic features, pattern of the inflammatory infiltrate and association of EC with other medical diseases, drugs and allergic states were evaluated. Results: Out of a total of 1370 cholecystectomy specimens received during five year period, Eosinophilic cholecystitis was diagnosed in 22 (1.6%) of the specimens. Clinically, seven of these patients had a clinical diagnosis of acute cholecystitis. Patient?s age ranged from 25-64 years and male to female ratio was 1:2.7. Most common symptom reported was abdominal pain. Most of the cases showed gallstones radiologically (90%) while only two cases showed peripheral eosinophilia (9%). Histologically, mucosal and muscular eosinophilic infiltrate was seen in 72.6% of the cases. No association with drug therapy, allergies or other pre-existing medical conditions was noted. Conclusion: EC is a relatively uncommon entity in which histopathology remains the main stay of diagnosis. Although the presentation may be similar to general cholecystitis, if a postoperative histopathological diagnosis of EC is made, then the patient must be investigated thoroughly to rule out other associated disease conditions, which may have a worse prognosis than cholecystitis itself.
机译：简介：胆囊疾病在印度北部非常常见，其中最常见的是慢性胆囊炎。当透壁细胞浸润液中90％以上为嗜酸性粒细胞时，很少有组织病理学诊断为嗜酸性胆囊炎（EC）。目的：确定新德里三级医院的嗜酸性胆囊炎的患病率和临床病理特征。材料和方法：这是一项回顾性临床病理研究，从2011年1月至2015年12月，为期5年，对22例嗜酸性胆囊炎进行了研究。在组织病理学诊断为嗜酸性胆囊炎的病例中，从医院记录中获得了临床细节并检索了载玻片。评估了各种组织学特征，炎性浸润的模式以及EC与其他医学疾病，药物和过敏状态的关联。结果：五年期间总共收到1370例胆囊切除术标本，其中22例（1.6％）诊断为嗜酸性胆囊炎。临床上，这些患者中有7例临床诊断为急性胆囊炎。患者年龄为25-64岁，男女之比为1：2.7。报告的最常见症状是腹痛。大多数病例在放射学上显示胆结石（90％），而只有两个病例显示周围性嗜酸性粒细胞增多（9％）。从组织学上看，粘膜和肌肉嗜酸性粒细胞浸润的发生率为72.6％。没有发现与药物治疗，过敏或其他先前存在的医疗状况有关。结论：EC是一个相对罕见的实体，其组织病理学仍是诊断的主要依据。尽管其表现可能类似于一般的胆囊炎，但如果术后进行了EC的组织病理学诊断，则必须对患者进行彻底检查，以排除其他相关疾病，这些疾病的预后可能比胆囊炎本身差。

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