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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Comparative Study of High Sensitivity C-Reactive Protein and Metabolic Variables in Type 2 Diabetes Mellitus with and without Nephropathy BC01-BC04
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A Comparative Study of High Sensitivity C-Reactive Protein and Metabolic Variables in Type 2 Diabetes Mellitus with and without Nephropathy BC01-BC04

机译：2型糖尿病伴和不伴肾病的高敏感性C反应蛋白和代谢变量的比较研究BC01-BC04

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Introduction: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant which acts as a non-specific systemic marker of inflammation.Aim: To find out the relationship between serum hs-CRP and metabolic variables in Type 2 diabetic patients with and without nephropathy.Materials and Methods: The study group consists of 96 subjects that include non-diabetic healthy controls, Type 2 diabetic patients without any complications and patients with diabetic nephropathy. The study group composed of both genders aged 31-70 years and the subjects were reported fasting after 10-12 hour overnight fast. Venous blood and fresh urine samples in the morning were collected from all the study subjects. Data were analysed using Statistical Package for the Social Sciences (SPSS). Independent t-test was used to compare between the groups and Chi square test was used to find out the relationship between serum hs-CRP and metabolic variables.Results: The results showed a significantly (p0.05) between hs-CRP and HDL-Cholesterol in both diabetic and diabetic nephropathy subjects.Conclusion: Hs-CRP was strongly associated with the metabolic variables and predictors of cardiovascular risk in Type 2 diabetes mellitus with and without nephropathy. The hs-CRP might be considered as a predictor or illness indicator for the development of nephropathy and cardiovascular risk in Type 2 diabetic patients.
机译：简介：糖尿病肾病是2型糖尿病（T2DM）的严重慢性并发症，会损害生活质量，导致发病率和死亡率增加。高敏C反应蛋白（hs-CRP）是一种急性反应物，可作为炎症的非特异性全身性标志物。目的：了解2型糖尿病合并糖尿病患者血清hs-CRP与代谢变量之间的关系。材料和方法：研究组由96位受试者组成，包括非糖尿病健康对照组，无任何并发症的2型糖尿病患者和糖尿病肾病患者。研究组由年龄在31-70岁之间的男女组成，据报道受试者在禁食10-12小时后禁食过夜。早晨从所有研究对象中采集静脉血和新鲜尿液样本。使用社会科学统计软件包（SPSS）分析数据。采用独立t检验比较两组之间的差异，采用卡方检验比较血清hs-CRP与代谢变量之间的关系。结果：结果显示，hs-CRP与HDL-C之间有显着性（p0.05）。结论：Hs-CRP与患有和不患有肾病的2型糖尿病患者的代谢变量和心血管风险的预测因素密切相关。 hs-CRP可能被视为2型糖尿病患者肾病和心血管风险发展的预测指标或疾病指标。

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