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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Syringocystadenocarcinoma Papilliferum- An Uncommon Malignant Adnexal Neoplasm at an Unusual Location
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Syringocystadenocarcinoma Papilliferum- An Uncommon Malignant Adnexal Neoplasm at an Unusual Location

机译：膀胱囊腺癌Papilliferum-在异常位置的罕见恶性肾上腺肿瘤

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Syringocystadenocarcinoma Papilliferum (SCACP) is a rare adnexal malignant neoplasm. Most of the cases present with a long standing mass with a sudden progression in size. A 60-year-old female presented with history of swelling over the antero-lateral aspect of left thigh since three years. The lesion was associated with history of pain and ulceration. Grossly, the external surface showed three ulcerated areas. The largest ulcer measured 4×5.5 cm. On cut section, the tumour showed variegated appearance consisting of grey-white to pink areas, multiple cysts, focal necrosis and hemorrhagic areas. Microscopically, tumour cells were arranged in papillary configuration, solid sheets, tubular and acinar pattern. Individual tumour cells showed pleomorphic vesicular nucleus and mitotic figures. The intervening connective tissue showed dense chronic inflammatory cell infiltrate composed of lymphocytes, plasma cells and eosinophils. Also seen were areas of necrosis and Gamna-Gandy body. Based on histological features, a diagnosis of malignant appendageal tumour of the skin with apocrine differentiation, favouring SCACP was offered. By Immunohistochemistry (IHC), tumour cells showed focal positivity for CEA and negative for GCDFP-15. IHC may be helpful, but a pathologist has to primarily depend on the histopathological characteristics of the lesion for diagnosing the condition.
机译：蝶形囊腺癌Papilliferum（SCACP）是一种罕见的附件恶性肿瘤。大多数病例表现为长期站立的肿块，大小突然增加。一名60岁女性自三年以来就出现了左大腿前外侧肿胀的病史。病变与疼痛和溃疡病史有关。大体上，外表面显示出三个溃疡区域。最大的溃疡为4×5.5 cm。在切开的切片上，肿瘤表现出杂色的外观，包括灰白色至粉红色区域，多个囊肿，局灶性坏死和出血区域。在显微镜下，肿瘤细胞排列成乳头状，实心片状，管状和腺泡状。单个肿瘤细胞显示多形性水泡核和有丝分裂图。中间的结缔组织显示出由淋巴细胞，浆细胞和嗜酸性粒细胞组成的致密的慢性炎性细胞浸润。还可以看到坏死区域和Gamna-Gandy尸体。基于组织学特征，可诊断出具有高分泌分化的皮肤恶性阑尾肿瘤，有利于SCACP。通过免疫组织化学（IHC），肿瘤细胞对CEA呈局部阳性，对GCDFP-15呈阴性。 IHC可能会有所帮助，但病理学家必须主要依靠病变的组织病理学特征来诊断病情。

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