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首页> 外文期刊>Journal of bacteriology >A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics.
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A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics.

机译：链霉菌属中的r决定簇家族。它指定了对大环内酯类，林可酰胺和B型链霉菌素的诱导耐药性。

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Inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics in Streptomyces spp. comprises a family of diverse phenotypes in which characteristic subsets of the macrolide-lincosamide-streptogramin antibiotics induce resistance mediated by mono- or dimethylation of adenine, or both, in 23S ribosomal ribonucleic acid. In these studies, diverse patterns of induction specificity in Streptomyces and associated ribosomal ribonucleic acid changes are described. In Streptomyces fradiae NRRL 2702 erythromycin induced resistance to vernamycin B, whereas in Streptomyces hygroscopicus IFO 12995, the reverse was found: vernamycin B induced resistance to erythromycin. In a Streptomyces viridochromogenes (NRRL 2860) model system studied in detail, tylosin induced resistance to erythromycin associated with N6-monomethylation of 23S ribosomal ribonucleic acid, whereas in Staphylococcus aureus, erythromycin induced resistance to tylosin mediated by N6-dimethylation of adenine. Inducible macrolide-lincosamide-streptogramin resistance was found in S. fradiae NRRL 2702 and S. hygroscopicus IFO 12995, which synthesize the macrolides tylosin and maridomycin, respectively, as well as in the lincosamide producer Streptomyces lincolnensis NRRL 2936 and the streptogramin type B producer Streptomyces diastaticus NRRL 2560. A wide range of different macrolides including chalcomycin, tylosin, and cirramycin induced resistance when tested in an appropriate system. Lincomycin was active as inducer in S. lincolnensis, the organism by which it is produced, and streptogramin type B antibiotics induced resistance in S. fradiae, S. hygroscopicus, and the streptogramin type B producer S. diastaticus. Patterns of adenine methylation found included (i) lincomycin-induced monomethylation in S. lincolnensis (and constitutive monomethylation in a mutant selected with maridomycin), (ii) concurrent equimolar levels of adenine mono- plus dimethylation in S. hygroscopicus, (iii) monomethylation in S. fradiae (and dimethylation in a mutant selected with erythromycin), and (iv) adenine dimethylation in S. diastaticus induced by ostreogrycin B.
机译：在链霉菌属中对大环内酯，林可酰胺和B型链霉菌素抗生素具有诱导抗性。包括一系列不同的表型，其中大环内酯-林可酰胺-链霉菌素抗生素的特征性子集在23S核糖体核糖核酸中诱导由腺嘌呤的单-或二甲基化或这两者介导的耐药性。在这些研究中，描述了链霉菌中各种不同的诱导特异性模式以及相关的核糖体核糖核酸变化。在弗拉迪链霉菌NRRL 2702中，红霉素引起了对游霉素B的抗性，而在吸水链霉菌IFO 12995中，发现了相反的情况：游霉素B引起了对红霉素的抗性。在详细研究的链霉菌变色链霉菌（NRRL 2860）模型系统中，泰乐菌素诱导对23S核糖体核糖核酸N6-单甲基化的红霉素具有抗性，而在金黄色葡萄球菌中，红霉素诱导对腺嘌呤N6-二甲基化介导的泰乐菌素的抗性。在弗拉迪链霉菌NRRL 2702和吸水链球菌IFO 12995中分别发现了诱导大环内酯类-林可酰胺-链霉菌素的耐药性，它们分别合成了大环内酯类泰乐菌素和马里霉素，以及在林可酰胺生产者林肯链霉菌NRRL 2936和B型链霉菌素生产者链霉菌中。 diastaticus NRRL2560。在适当的系统中进行测试时，各种不同的大环内酯类药物包括查尔霉素，泰乐菌素和西拉霉素诱导的耐药性。林可霉素是林肯链球菌（S. lincolnensis）的诱生剂，林肯霉素是由其产生的生物，而链霉菌素B型抗生素可在桔梗链霉菌，吸水链球菌和B链霉菌产生者S. diastaticus中产生抗药性。发现的腺嘌呤甲基化模式包括（i）林肯霉素诱导的林肯链球菌单甲基化（和在用马来霉素选择的突变体中组成型单甲基化），（ii）吸水链球菌同时存在等摩尔水平的腺嘌呤单加甲基化，（iii）单甲基化（在红霉素选择的突变体中进行二甲基化）和（iv）在骨链球菌B诱导下的S.diastaticus中进行腺嘌呤二甲基化。

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