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首页> 外文期刊>Journal of bacteriology >Influence of molecular size and osmolarity of sugars and dextrans on the synthesis of outer membrane proteins O-8 and O-9 of Escherichia coli K-12.
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Influence of molecular size and osmolarity of sugars and dextrans on the synthesis of outer membrane proteins O-8 and O-9 of Escherichia coli K-12.

机译：糖和葡聚糖的分子大小和摩尔渗透压浓度对大肠杆菌K-12外膜蛋白O-8和O-9合成的影响。

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Supplementation of the growth medium with high concentrations of sugars or low-molecular-weight dextrans results in a drastic change in the ratio of outer membrane proteins O-8 and O-9, due to induction of O-8 synthesis and suppression of O-9 synthesis. Sugars and dextrans of molecular weights greater than 600 to 700 switched the synthesis of O-9 to that of O-8 more effectively than those of lower molecular weight, although the effect was almost the same within each of the two groups irrespective of the differences in molecular weight within the group. Proteins O-8 or O-9, or both, are responsible for the formation of pores that allow the passive diffusion of hydrophilic molecules whose molecular weights are smaller than about 600 (T. Nakae, Biochem. Biophys. Res. Commun. 71:877-884, 1976). The results indicate that substances that cannot pass through the outer membrane switch the synthesis of O-9 to that of O-8 more effectively than those that can penetrate this membrane with the aid of O-8, O-9, or both. It is suggested that the osmotic pressure exerted on the outer membrane plays an important role in the regulation of synthesis of the two proteins.
机译：在生长培养基中添加高浓度的糖或低分子量的右旋糖酐，会导致外膜蛋白O-8和O-9的比例发生剧烈变化，这是由于O-8合成的诱导和O-的抑制9合成。分子量大于600至700的糖和右旋糖酐比低分子量的糖和葡聚糖更有效地将O-9合成为O-8，尽管两组之间的效果几乎相同，而不论差异如何在组内的分子量。蛋白O-8或O-9或两者共同负责形成孔，这些孔允许分子量小于600的亲水性分子被动扩散（T.Nakae，Biochem.Biophys.Res.Commun.71： 877-884，1976）。结果表明，不能通过外膜的物质比通过O-8，O-9或两者都能穿透该膜的物质更有效地将O-9的合成转换为O-8。提示施加在外膜上的渗透压在调节两种蛋白质的合成中起重要作用。

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