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首页> 外文期刊>Journal of bacteriology >Induction of ermC methylase in the absence of macrolide antibiotics and by pseudomonic acid A.
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Induction of ermC methylase in the absence of macrolide antibiotics and by pseudomonic acid A.

机译：在不存在大环内酯类抗生素和pseudo酸A的情况下诱导ermC甲基化酶。

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摘要

The methylase encoded by erm genes and induced by erythromycin modifies the 23S rRNA and confers resistance to macrolide-lincosamide-streptogramin B antibiotics. Induction is due to a posttranscriptional mechanism in which the inducer activates translation of methylase mRNA by binding to unmethylated (erythromycin-sensitive) ribosomes and stalling them in the leader region. It is shown in this study that pseudomonic acid A, an inhibitor of isoleucyl-tRNA synthetase, can also induce methylase synthesis. Isoleucine starvation has a similar effect on ribosomes translating the ermC leader region to cause induction of methylase synthesis. These observations support the requirements for ribosome stalling and destabilization of a stem-loop structure and demonstrate that stalling can occur without macrolide-bound ribosomes.
机译：由erm基因编码并由红霉素诱导的甲基化酶修饰23S rRNA并赋予对大环内酯-林可酰胺-链霉菌素B抗生素的抗性。诱导归因于转录后机制，其中诱导剂通过结合未甲基化（对红霉素敏感的）核糖体并将其停滞在前导区中而激活甲基化酶mRNA的翻译。这项研究表明，异亮氨酰-tRNA合成酶的抑制剂假单酸A也可以诱导甲基化酶的合成。异亮氨酸饥饿对核糖体翻译ermC前导区引起甲基化酶合成的诱导具有类似的作用。这些观察结果支持核糖体停滞和茎环结构不稳定的要求，并证明没有大环内酯结合的核糖体可以发生停滞。

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