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首页> 外文期刊>Journal of bacteriology >Increased carbohydrate substitution of lipoteichoic acid during inhibition of protein synthesis.
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Increased carbohydrate substitution of lipoteichoic acid during inhibition of protein synthesis.

机译:在抑制蛋白质合成过程中增加脂联磷酸的碳水化合物取代。

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摘要

Decreases in electrophoretic mobilities of intracellular lipoteichoic acid, intracellular deacylated lipoteichoic acid, and extracellular deacylated lipoteichoic acid were observed during inhibition of protein synthesis in Streptococcus faecium after exposure to chloramphenicol or valine deprivation. Increased carbohydrate content, and thus an increased mass-to-charge ratio, rather than changes in ester alanine content or novel fatty acid substitutions, appeared to account for the decreased electrophoretic mobilities. The increase in carbohydrate content, as judged from mobility measurements, was progressive over time and appeared to occur on biosynthetically new lipoteichoic acid as well as on lipoteichoic acid made before inhibition of protein synthesis.
机译:在暴露于氯霉素或缬氨酸剥夺后,粪便链球菌蛋白质合成受到抑制时,观察到细胞内脂蛋白,胞内脱酰脂蛋白和胞外脱酰脂蛋白的电泳迁移率降低。碳水化合物含量的增加,从而质荷比的增加,而不是酯丙氨酸含量的变化或新的脂肪酸取代,似乎是电泳迁移率下降的原因。根据迁移率测量结果判断,碳水化合物含量的增加随着时间的推移逐渐增加,并且似乎发生在生物合成的新脂蛋白酸以及抑制蛋白质合成之前制备的脂蛋白酸上。

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