...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of bacteriology >Nucleotide sequence of pvdD, a pyoverdine biosynthetic gene from Pseudomonas aeruginosa: PvdD has similarity to peptide synthetases.
【24h】

Nucleotide sequence of pvdD, a pyoverdine biosynthetic gene from Pseudomonas aeruginosa: PvdD has similarity to peptide synthetases.

机译：pvdD（铜绿假单胞菌的pyoverdine生物合成基因）的核苷酸序列：PvdD与肽合成酶相似。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pseudomonas aeruginosa secretes a fluorescent siderophore, pyoverdine, when grown under iron-deficient conditions. Pyoverdine consists of a chromophoric group bound to a partly cyclic octapeptide. As a step toward understanding the molecular events involved in pyoverdine synthesis, we have sequenced a gene, pvdD, required for this process. The gene encodes a 2,448-residue protein, PvdD, which has a predicted molecular mass of 273,061 Da and contains two highly similar domains of about 1,000 amino acids each. The protein is similar to peptide synthetases from a range of bacterial and fungal species, indicating that synthesis of the peptide moiety of pyoverdine proceeds by a nonribosomal mechanism. The pvdD gene is adjacent to a gene, fpvA, which encodes an outer membrane receptor protein required for uptake of ferripyoverdine.
机译：在缺铁条件下生长时，铜绿假单胞菌会分泌一种荧光铁载体吡啶酮。 Pyoverdine由与部分环状八肽结合的发色基团组成。为了理解吡啶酮合成中涉及的分子事件，我们对这一过程所需的基因pvdD进行了测序。该基因编码2448个残基蛋白质PvdD，其预测分子量为273,061 Da，并包含两个高度相似的结构域，每个结构域约1,000个氨基酸。该蛋白质类似于来自一系列细菌和真菌物种的肽合成酶，这表明吡非定的肽部分的合成是通过非核糖体机制进行的。 pvdD基因与fpvA基因相邻，后者编码摄取ferripyoverdine所需的外膜受体蛋白。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号