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首页> 外文期刊>Journal of bacteriology >Regulation of rns, a positive regulatory factor for pili of enterotoxigenic Escherichia coli.
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Regulation of rns, a positive regulatory factor for pili of enterotoxigenic Escherichia coli.

机译：rns的调节，是产肠毒素大肠杆菌的菌毛的阳性调节因子。

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摘要

Attachment of enterotoxigenic Escherichia coli to the human gut is considered an important early step in infection that leads to diarrhea. This attachment is mediated by pili, which belong to a limited number of serologically distinguishable types. Many of these pili require the product of rns, or a closely related gene, for their expression. We have located the major promoter for rns and found that although its sequence diverges significantly from a sigma-70 promoter consensus sequence, it is very strong. Transcription of rns is negatively regulated both at a region upstream of this promoter and at a region internal to the rns open reading frame. In addition, rns positively regulates its own transcription, probably by counteracting these two negative effects.
机译：肠毒素原性大肠杆菌与人肠道的附着被认为是导致腹泻的重要感染早期步骤。这种附着是由菌毛介导的，菌毛属于数量有限的血清学上可区分的类型。这些菌毛中的许多需要rns的产物或紧密相关的基因才能表达。我们找到了rns的主要启动子，发现尽管其序列与sigma-70启动子共有序列有显着差异，但它非常强。 rns的转录在该启动子的上游区域和rns开放阅读框内部的区域均受到负调控。此外，rns可能通过抵消这两个负面影响来积极调节其自身的转录。

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