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首页> 外文期刊>Journal of bacteriology >The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation.
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The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation.

机译：大肠杆菌链霉菌A3（2）的ppGpp合成酶基因（relA）在抗生素生产和形态分化中起条件性作用。

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摘要

Deletion of most of the coding region of the ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) resulted in loss of ppGpp synthesis, both upon entry into stationary phase under conditions of nitrogen limitation and following amino acid starvation during exponential growth, but had no effect on growth rate. The relA mutant, which showed continued rRNA synthesis upon amino acid depletion (the relaxed response), failed to produce the antibiotics undecylprodigiosin (Red) and actinorhodin (Act) under conditions of nitrogen limitation. The latter appears to reflect diminished transcription of pathway-specific regulatory genes for Red and Act production, redD and actII-ORF4, respectively. In addition to the changes in secondary metabolism, the relA mutant showed a marked delay in the onset and extent of morphological differentiation, resulting in a conspicuously altered colony morphology.
机译：缺失链霉菌A3（2）的ppGpp合成酶基因（relA）的大多数编码区会导致ppGpp合成的损失，这既是在氮限制条件下进入固定相时，又是在指数增长过程中出现氨基酸饥饿之后。对增长率没有影响。 relA突变体在氨基酸消耗后显示出连续的rRNA合成（松弛反应），但在氮限制的条件下未能产生抗生素十一碳黄素（Red）和放线菌素（Act）。后者似乎分别反映了Red和Act生产，redD和actII-ORF4的途径特异性调控基因的转录减少。除了次级代谢的变化外，relA突变体在形态学分化的发生和程度方面显示出明显的延迟，从而导致菌落形态的显着改变。

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