...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of bacteriology >Undecaprenyl Pyrophosphate Involvement in Susceptibility of Bacillus subtilis to Rare Earth Elements
【24h】

Undecaprenyl Pyrophosphate Involvement in Susceptibility of Bacillus subtilis to Rare Earth Elements

机译：十一碳烯基焦磷酸酯参与枯草芽孢杆菌对稀土元素的敏感性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The rare earth element scandium has weak antibacterial potency. We identified a mutation responsible for a scandium-resistant phenotype in Bacillus subtilis. This mutation was found within the uppS gene, which encodes undecaprenyl pyrophosphate synthase, and designated uppS86 (for the Thr-to-Ile amino acid substitution at residue 86 of undecaprenyl pyrophosphate synthase). The uppS86 mutation also gave rise to increased resistance to bacitracin, which prevents cell wall synthesis by inhibiting the dephosphorylation of undecaprenyl pyrophosphate, in addition to enhanced amylase production. Conversely, overexpression of the wild-type uppS gene resulted in increased susceptibilities to both scandium and bacitracin. Moreover, the mutant lacking undecaprenyl pyrophosphate phosphatase (BcrC) showed increased susceptibility to all rare earth elements tested. These results suggest that the accumulation of undecaprenyl pyrophosphate renders cells more susceptible to rare earth elements. The availability of undecaprenyl pyrophosphate may be an important determinant for susceptibility to rare earth elements, such as scandium.
机译：稀土元素scan的抗菌能力很弱。我们确定了一个突变导致枯草芽孢杆菌中的scan抗性表型。该突变存在于 uppS 基因内，该基因编码十一碳二烯基焦磷酸合酶，并命名为 uppS86 （用于十一碳烯基焦磷酸合酶残基86处的Thr-Ile氨基酸取代） ）。 uppS86 突变还增加了对杆菌肽的抗性，除了增强淀粉酶的产生外，它还通过抑制十一碳烯基焦磷酸的去磷酸化来阻止细胞壁合成。相反，野生型 uppS 基因的过表达导致对scan和杆菌肽的敏感性增加。此外，缺乏十一碳烯基焦磷酸磷酸酶（BcrC）的突变体显示出对所有测试的稀土元素的敏感性增加。这些结果表明十一碳烯基焦磷酸的积累使细胞更容易受到稀土元素的影响。十一碳烯基焦磷酸的可利用性可能是对稀土元素（如）敏感性的重要决定因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号