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首页> 外文期刊>Scientific reports. >Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer
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Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer

机译：两种口腔癌前体和癌症中mir31和CXCL12的表达失调：在癌前体和癌症进展中的重要性

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Oral cancer generally progresses from precancerous lesions such as leukoplakia (LK), lichen planus (LP) and oral submucous fibrosis (OSMF). Since few of these precancers progress to cancers; it is worth to identify biological molecules that may play important roles in progression. Here, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their possible target genes in 23 cancers, 18 LK, 12 LP, 23 OSMF tissues compared to 20 healthy tissues was determined by qPCR method. Expression of mir7, mir31, mir31* and mir1293 was upregulated and that of mir133a, mir204 and mir206 was downregulated in cancer. Expression of most of these miRNAs was also upregulated in LK and LP tissues but not in OSMF. Expression deregulation of some of the target genes was also determined in cancer, LK and LP tissues. Significant upregulation of mir31 and downregulation of its target gene, CXCL12, in cancer, LK and LP tissues suggest their importance in progression of precancer to cancer. Expression upregulation of mir31 was also validated using GEO data sets. Although sample size is low, novelty of this work lies in studying expression deregulation of miRNAs and target genes in oral cancer and three types of precancerous lesions.
机译：口腔癌通常由癌前病变如白斑（LK），扁平苔藓（LP）和口腔粘膜下纤维化（OSMF）发展而成。由于这些癌症中的极少数会发展为癌症;值得鉴定在进展中可能起重要作用的生物分子。在这里，通过qPCR确定了相对于20种健康组织，在23种癌症，18 LK，12 LP，23 OSMF组织中的7种miRNA（mir204，mir31，mir31 *，mir133a，mir7，mir206和mir1293）及其可能的靶基因的表达失调。方法。在癌症中，mir7，mir31，mir31 *和mir1293的表达上调，而mir133a，mir204和mir206的表达下调。在LK和LP组织中，大多数这些miRNA的表达也被上调，而在OSMF中则没有。在癌症，LK和LP组织中也确定了一些靶基因的表达失调。在癌症，LK和LP组织中，mir31的显着上调及其目标基因CXCL12的下调表明它们在癌前期癌症发展中的重要性。还使用GEO数据集验证了mir31的表达上调。尽管样本量很小，但是这项工作的新颖之处在于研究了口腔癌和三种癌前病变中miRNA和靶基因的表达失调。

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