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首页> 外文期刊>World Journal of Gastroenterology >Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study
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Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study

机译：利用新开发的PGSAS-45规模评估，影响胃切除术后患者生活质量的因素：全国范围内的多制度研究

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AIM To identify certain clinical factors other than the type of gastrectomy which affect the postoperative quality of life (QOL) of patients after gastrectomy. METHODS The postgastrectomy syndrome assessment scale (PGSAS)-45 was designed to assess the severity of symptoms, the living status and the QOL of gastrectomized patients. It consists of 45 items, of which 22 are original items while 23 were retrieved from the SF-8 and Gastrointestinal Symptoms Rating Scale questionnaires with permission. A nationwide surveillance study to validate PGSAS was conducted and 2368 gastric cancer patients who underwent various types of gastrectomy at 52 medical institutions were enrolled. Of these, 1777 patients who underwent total gastrectomy (TG) reconstructed with Roux-Y ( n = 393), distal gastrectomy (DG) reconstructed with Billroth-I ( n = 909), or DG reconstructed with Roux-Y ( n = 475) were evaluated in the current study. The influence of the type of gastrectomy and other clinical factors such as age, sex, duration after surgery, the symptom severity, the degree of weight loss, dietary intake, and the ability for working on the postoperative QOL ( i.e ., dissatisfaction for daily life subscale, physical component summary and mental component summary of the SF-8) were examined by multiple regression analysis (MRA). In addition, importance of various symptoms such as esophageal reflux, abdominal pain, meal-related distress, indigestion, diarrhea, constipation and dumping on the postoperative living status and QOL were also appraised by MRA. RESULTS The postoperative QOL were significantly deteriorated in patients who underwent TG compared to those after DG. However, the extent of gastrectomy was not an influential factor on patients’ QOL when adjusted by the MRA. Among various clinical factors, the symptom severity, ability for working, and necessity for additional meals were the most influential factors to the postoperative QOL. As for the individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected the postoperative QOL in that order, while the influence of indigestion, diarrhea and constipation was insignificant. CONCLUSION Several clinical factors such as the symptom severity (especially in meal-related distress and dumping), ability for working and necessity for additional meals were the main factors which affected the patients’ well-being after gastrectomy.
机译：目的是识别除胃切除后患者术后生命质量（QOL）术后生命质量（QOL）的胃切除术以外的某些临床因素。方法旨在评估症状，生活地位和胃肠株株的严重程度，旨在评估症状的严重程度，胃癌患者的严重程度。它由45个项目组成，其中22个是原始物品，而在SF-8和胃肠道症状评级规模问卷中检出23，允许使用。进行了验证PGSA的全国监测研究，并参加了2368名在52名医疗机构进行各种胃切除术的胃癌患者。其中1777名患有Roux-y（n = 393）的总胃切除术（Tg）的患者，与Billroth-i（n = 909）重建的远端胃切除术（Dg），或与Roux-Y重建的DG（n = 475 ）在目前的研究中进行了评估。胃切除术和其他临床因素的类型的影响，术后，性别，持续时间，症状严重程度，减肥程度，膳食摄入程度以及在术后QOL工作的能力（即，每日不满通过多元回归分析（MRA）检查了SF-8）的生命子等，物理组件摘要和SF-8的心理组件摘要。此外，MRA也对各种症状如食管反流，腹痛，膳食，膳食，便秘和倾销等各种症状，腹痛，膳食相关困扰，消化不良，腹泻，便秘和倾销等各种症状也得到了评估。结果术后QOL与DG后的TG相比，术后QOL显着恶化。然而，胃切除术的程度不是MRA调整时患者QOL的影响因素。在各种临床因素中，症状严重程度，工作能力以及额外膳食的必要性是术后QoL最有影响力的因素。至于个体症状，与膳食相关的痛苦，倾销，腹痛和食管反流显着影响术后QoL，而消化不良，腹泻和便秘的影响是微不足道的。结论几种临床因素，如症状严重程度（特别是与膳食相关的痛苦和倾销），工作能力和额外膳食的必要性是影响患者在胃切除后患者良好的主要因素。

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