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首页> 外文期刊>Balkan journal of medical genetics: BJMG >RANKL is a new epigenetic biomarker for the vasomotor symptom during Menopause
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RANKL is a new epigenetic biomarker for the vasomotor symptom during Menopause

机译：Rankl是一种新的表观遗传生物标志物，用于血管血管症状期间更年期

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During menopausal transition, decreased level of estrogen brings a number of physiological problems and hormonal changes. In this study, promoter methylation of RANKL and FSHR genes were identified in 30 premenopausal and 35 postmenopausal women using methylation-specific high resolution melting (MS-HRM) analysis. The statistical analyses and their association with patient characteristics were performed by Pearson ??2 and Fishera??s exact test (p 0.05). The methylated RANKL gene was detected in 16 postmenopausal cases, and 12 (75.0%) of the RANKL methylated cases had hot flashes (p = 0.024). The methylated FSHR gene was detected in 18 postmenopausal cases, and 13 (75.0%) of the methylated cases had hot flashes (p = 0.028). In vitro studies demonstrated the association between RANKL expression, FSH level and hot flashes in the mouse. Although lack of epigenetic studies in this field proves our results crucial and therefore, our results showed magnitude of epigenetic profiles of Turkish Cypriot post-menopausal women. This was the first study which has investigated the RANKL and FSHR methylation and their relationship with hot flashes in postmenopausal women.
机译：在更年期过渡期间，雌激素水平降低地带来了许多生理问题和激素变化。在该研究中，使用甲基化特异性高分辨率熔化（MS-HRM）分析，在30位前所未经高分子妇女中鉴定了RANKL和FSHR基因的启动子甲基化。统计分析及其与患者特征的关联由Pearson进行确切的测试（P <0.05）进行。在甲基化rankL基因中在16例绝经后病例中检测到，12（75.0％）的RANKL甲基化病例具有热闪烁（P = 0.024）。在18例绝经外病例中检测到甲基化的FSHR基因，13例（75.0％）的甲基化病例具有热闪烁（P = 0.028）。体外研究证明了鼠标中的RANKL表达，FSH水平和热闪烁之间的关联。虽然这一领域的表观遗传研究缺乏证明我们的结果至关重要，但我们的结果表明，土耳其语塞浦路斯后绝经妇女的表观遗传谱的大小。这是第一项研究，该研究已经调查了牛犊和FSHR甲基化及其与绝经后妇女的热闪光的关系。

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