• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Balkan journal of medical genetics: BJMG >Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents
【24h】

Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

机译：脑衍生的神经营养因子Val66met多态性与体重指数，青少年血液葡萄糖水平和脂质地位的关联

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Brain-derived neurotrophic factor (BDNF) has an important role in energy balance. It suppresses food intake, reduces hepatic glucose production and converts white fat into brown fat in adipose tissue, leading to energy dissipation, lowered blood glucose and a lean phenotype. Studies have shown that the single nucleotide polymorphism (SNP) Val66Met within BDNF may be associated with obesity, insulin sensitivity, type 2 diabetes mellitus (T2DM) and dyslipidemia. The objective of the study was to investigate the association of the Val66Met polymorphism with body mass index (BMI), fasting glucose levels and lipid profile in Serbian adolescents. The study included 308 randomly selected healthy adolescents, 153 (49.68%) boys and 155 girls (50.32%), 15 years of age. Data including age, gender, height, weight, lipid profile and fasting glucose were recorded. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No association of this polymorphism was found with BMI and lipid profile. However, significant association was observed between this polymorphism and fasting blood glucose (FBG). Carriers of a Val/Val genotype had significantly higher mean values of fasting glucose level compared to carriers of Val/ Met and Met/Met genotypes (p = 0.01). To confirm these results multiple linear regression analysis was performed. Body mass index and gender were taken as covariates. Carriers of the Val/Val genotype had significantly higher levels of FBG (?2 = -0.152, p = 0.02). A statistically significant association between BMI and glucose level was also observed (?2 = 0.124,p = 0.033). This polymorphism could be associated with fasting glucose level in Serbian adolescents, thus further research would be of great interest to validate these results.
机译：脑衍生的神经营养因子（BDNF）在能量平衡中具有重要作用。它抑制食物摄入量，减少了肝葡萄糖生产，并将白脂转化为脂肪组织中的棕色脂肪，导致能量耗散，降低血糖和瘦表型。研究表明，BDNF内的单核苷酸多态性（SNP）Val66mmet可能与肥胖，胰岛素敏感性，2型糖尿病（T2DM）和血脂血症相关。该研究的目的是研究Val66met多态性与体重指数（BMI）的关联，塞尔维亚青少年的空腹葡萄糖水平和脂质分布。该研究包括308名随机选择的健康青少年，153名（49.68％）男孩和155名女孩（50.32％），15岁。记录了包括年龄，性别，高度，体重，脂质曲线和空腹葡萄糖的数据。基因分型通过聚合酶链反应限制片段长度多态性（PCR-RFLP）方法进行。没有发现这种多态性的关联，并用BMI和脂质分布发现。然而，这种多态性和空腹血糖（FBG）之间观察到了显着的关联。与Val / Met的载体和Met / Met基因型的载体相比，Val / Val基因型的载体具有明显更高的空腹葡萄糖水平值（P = 0.01）。要确认这些结果，请执行多个线性回归分析。体重指数和性别被视为协变量。 Val / Val基因型的载体含量明显高，FBG水平（α2= -0.152，p = 0.02）。还观察到BMI和葡萄糖水平之间的统计学上显着的关联（α2= 0.124，p = 0.033）。这种多态性可能与塞尔维亚青少年的空腹血糖水平相关，因此进一步的研究对于验证这些结果有很大的兴趣。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号