...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Rheumatology international. >A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein.
【24h】

A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein.

机译：脑源性神经营养因子多态性Val66Met可识别出具有较高体重指数和C反应蛋白的纤维肌痛综合征亚组。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A common single nucleotide polymorphism (SNP) in the gene of brain-derived neurotrophic factor (BDNF) results from a substitution at position 66 from valine (Val) to methionine (Met) and may predispose to human neuropsychiatric disorders. We proposed to determine whether these BDNF gene SNPs were associated with fibromyalgia syndrome (FMS) and/or any of its typical phenotypes. Patients with FMS (N?=?95) and healthy normal controls (HNC, N?=?58) were studied. Serum high-sensitivity C-reactive protein (hsCRP) levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BDNF SNPs were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The BDNF SNP distribution was 65 (68%) Val/Val, 28 (30%) Val/Met, and 2 (2%) Met/Met for FMS and 40 (69%), 17(29%), and 1 (2%) for HNC, respectively. The serum high-sensitivity C-reactive protein (hsCRP)and body mass index (BMI) in FMS were higher than in HNC. The FMS with BDNF Val66Val had significantly higher mean BMI (P?=?0.0001) and hsCRP (P?=?0.02) than did FMS carrying the Val66Met genotype. This pattern was not found in HNC. Phenotypic measures of subjective pain, pain threshold, depression, or insomnia did not relate to either of the BDNF SNPs in FMS. The relative distribution BDNF SNPs did not differ between FMS and HNC. The BDNF Val66Met polymorphism is not selective for FMS. The BDNF Val66Val SNP identifies a subgroup of FMS with elevated hsCRP and higher BMI. This is the first study to associate a BDNF polymorphism with a FMS subgroup phenotype.
机译：脑源性神经营养因子（BDNF）基因中常见的单核苷酸多态性（SNP）是由缬氨酸（Val）置换为蛋氨酸（Met）引起的66位取代，可能导致人类神经精神疾病。我们建议确定这些BDNF基因SNP是否与纤维肌痛综合征（FMS）和/或其任何典型表型有关。研究了具有FMS（N？=？95）和健康正常对照（HNC，N？=？58）的患者。使用酶联免疫吸附测定（ELISA）测量血清高敏C反应蛋白（hsCRP）水平。使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）确定BDNF SNPs.BDNF SNP分布为65（68％）Val / Val，28（30％）Val / Met和2（2％）Met FMS为/ Met，HNC为40（69％），17（29％）和1（2％）。 FMS的血清高敏C反应蛋白（hsCRP）和体重指数（BMI）高于HNC。带有BDNF Val66Val的FMS具有比带有Val66Met基因型的FMS更高的平均BMI（P <= 0.0001）和hsCRP（P <= 0.02）。在HNC中找不到此模式。在FMS中，主观疼痛，疼痛阈值，抑郁或失眠的表型测量与BDNF SNP都不相关。 FMS和HNC之间的相对分布BDNF SNP没有差异。 BDNF Val66Met多态性对FMS不具有选择性。 BDNF Val66Val SNP可识别出具有高hsCRP和更高BMI的FMS亚组。这是第一项将BDNF多态性与FMS亚型表型相关联的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号