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首页> 外文期刊>BMC Ophthalmology >Longitudinal observation of OCT imaging is a valuable tool to monitor primary vitreoretinal lymphoma treated with intravitreal injections of methotrexate
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Longitudinal observation of OCT imaging is a valuable tool to monitor primary vitreoretinal lymphoma treated with intravitreal injections of methotrexate

机译：OCT成像的纵向观察是一种有价值的工具，用于监测用甲氨蝶呤含有玻璃氨酸纤维素注射治疗的原发性玻璃体淋巴瘤

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Developing objective and repeatable indicators to evaluate the efficacy of PVRL treatment is important. The quantification of vitreous cells is a traditional criterion; however slight changes are difficult to ascertain. Spectral domain optical coherence tomography (SD-OCT) is objective, repeatable, and easily explained. The purpose of this study is to provide a longitudinal observation of OCT in PVRL treated with intravitreal injections of methotrexate (MTX) and to evaluate the utility of OCT in monitoring responsiveness of PVRL to treatment. The medical records of patients with biopsy-positive PVRL attending our hospital between January 2016 and September 2017 who received intravitreal injections of MTX were included in this study. Pre- and post-treatment OCT images were reviewed independently by two researchers. Of the 24 cases reviewed, 10 patients (18 eyes) were included. SD-OCT abnormalities at the initial visit included vitreous cells (18/18), OR (outer retina) fuzzy borders (12/18), PED (pigment epithelium detachments) (9/18), subretinal hyperreflective infiltration (3/18), intraretinal infiltration (8/18), and SRF (subretinal fluid) (4/18). Post induction treatment, SRF in cases with RD (retinal detachment) was absorbed, and subretinal fibrosis appeared. Other lesions were significantly reduced. Post consolidation treatment, OR fuzzy borders, PED and SRF disappeared in 2 eyes, intraretinal infiltration disappeared in 1 eye, and other abnormalities further improved. Additionally, retinal fibrosis was observed in 3 eyes. One month post maintenance treatment, all abnormalities observed at the first visit vanished. At the last visit, OCT showed subretinal fibrosis and in 3 eyes (16.7%), the disruption of outer retina in 9 eyes (50%) and thinning of the whole layer in 4 eyes (22.2%). Our observations reveal that characteristic OCT features in PVRL patients can reduce gradually and finally vanish with therapy. We propose that SD-OCT may be employed to monitor the responsiveness of PVRL to treatment, which may influence decision making in the management of this disease.
机译：开发目标和可重复指标评估PVRL治疗的功效是重要的。玻璃体细胞的量化是传统的标准;然而，难以确定的变化很难确定。光谱域光学相干断层扫描（SD-OCT）是客观的，可重复的，并且容易解释。本研究的目的是提供含有甲氨蝶呤（MTX）的玻璃氨酸纤维素注射治疗的OCT在PVR1中的纵向观察，并评估OCT的效用在监测PVRL对治疗的反应性。在本研究中纳入了2016年1月至2017年9月在2017年1月至2017年9月期间参加过医院的活组织检查阳性PVRL患者的病程。治疗前和后后OCT图像由两位研究人员独立审查。在24例审查的情况下，包括10名患者（18只眼）。初始访问的SD-OCT异常包括玻璃体细胞（18/18），或（外视网膜）模糊边框（12/18），PED（颜料上皮脱离）（9/18），副术过重选择性浸润（3/18） ，intraretinal浸润（8/18）和srf（次阈流体）（4/18）。诱导后治疗后，在RD（视网膜脱离）的情况下SRF被吸收，并且出现了伯序纤维化。其他病变明显减少。结束治疗后，或模糊边界，PED和SRF在2只眼中消失，Intraretinal渗透在1只眼中消失，其他异常进一步改善。另外，在3只眼睛中观察到视网膜纤维化。一个月后维修治疗，第一次访问后观察到的所有异常都消失了。在最后一次访问中，OCT显示骨折纤维化和3只眼（16.7％），在4只眼中的9只眼睛（50％）中的外视对外视网膜的破坏，并在4只眼中稀释整层（22.2％）。我们的观察结果表明，PVRL患者的特征OCT特征可以逐渐减少，最终会因治疗而消失。我们建议可以使用SD-OCT来监测PVRL对治疗的响应，这可能影响在该疾病的管理中的决策。

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