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Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring

机译：父亲先注蒸气暴露范式对后代行为响应的影响

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We and others previously reported that paternal preconception chronic ethanol exposure leads to molecular, physiological, and behavioral changes in offspring including reduced ethanol consumption and preference relative to controls. The goal of the present study was to further explore the impact of paternal ethanol exposure on a wide variety of basal and drug-induced behavioral responses in first generation offspring. Adult male mice were exposed to chronic intermittent vapor ethanol or control conditions for 5–6 weeks before being mated with ethanol-na?ve females to produce ethanol (E)- and control (C)-sired offspring. E-sired male offspring showed stress hyporesponsivity in a stress-induced hyperthermia assay and E-sired female offspring had reduced binge-like ethanol consumption in a drinking in the dark assay compared to C-sired offspring. E-sired offspring also showed altered sensitivity to a sedative/hypnotic dose of the GABAergic drug midazolam, but not ketamine or ethanol, in a loss of the righting response assay. E-sired offspring did not differ from controls in marble burying, novel object location, novel object recognition, social interaction, bottle-brush, novelty suppressed feeding, prepulse inhibition, every-other-day ethanol drinking, or home cage activity assays. This study adds to a growing body of literature suggesting that like in utero alcohol exposure, paternal preconception alcohol exposure can also have effects that persist and impact behavior of offspring.
机译：我们和其他人以前报道，父亲的先注慢性乙醇暴露导致后代的分子，生理和行为变化，包括降低乙醇消耗和相对于对照的偏好。本研究的目的是进一步探讨父乙醇暴露对第一代后代各种基础和药物诱导的行为反应的影响。将成年雄性小鼠暴露于慢性间歇蒸气乙醇或对照条件5-6周，然后与乙醇-NA've雌性配合，以产生乙醇（E） - 和对照（C）的后代。 e-inded雄性后代显示应激诱导的热疗测定中的应激性低回归性，与C次的后代相比，e-in雌性后代在暗视图中的饮用中的饮用中的泪水等乙醇消耗量降低。 E-Iafired Depspring还表明，在抗恢复测定的损失中，对镇静剂/催眠剂量的镇静剂/催眠剂量的镇静剂/催眠剂量的沉重/催眠剂量的敏感性改变了敏感性药物，而不是氯胺酮或乙醇。 E-Irifired Depspring与大理石埋葬的控制没有差异，新的对象位置，新的对象识别，社交互动，瓶刷，新奇抑制喂养，预筛选，每日乙醇饮用或家庭笼子活性测定。本研究增加了一种越来越多的文献，表明，就像在子宫酒精暴露中一样，父亲的先注酒精暴露也可能产生持续和后代的影响行为的影响。

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