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首页> 外文期刊>Alcohol >Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background
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Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background

机译：父亲的先入化酒精曝光使纯C57BL / 6J背景上的男性后代赋予代际醇类相关行为

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While alcohol use disorder (AUD) is a highly heritable condition, the basis of AUD in families with a history of alcoholism is difficult to explain by genetic variation alone. Emerging evidence suggests that parental experience prior to conception can affect inheritance of complex behaviors in offspring via non-genomic (epigenetic) mechanisms. For instance, male C57BL/6J (B6) mice exposed to chronic intermittent vapor ethanol (CIE) prior to mating with Strain 129S1/SvImJ ethanol-naive females produce male offspring with reduced ethanol-drinking preference, increased ethanol sensitivity, and increased brain derived neurotrophic factor (BDNF) expression in the ventral tegmental area (VTA). In the present study, we tested the hypothesis that these intergenerational effects of paternal CIE are reproducible in male offspring on an inbred B6 background. To this end, B6 males were exposed to 6 weeks of CIE (or room air as a control) before mating with ethanol-naive B6 females to produce ethanol (E)-sired and control (C)-sired male and female offspring. We observed a sex-specific effect, as E-sired males exhibited decreased two-bottle free-choice ethanol-drinking preference, increased sensitivity to the anxiolytic effects of ethanol, and increased VTA BDNF expression; no differences were observed in female offspring. These findings confirm and extend our previous results by demonstrating that the effects of paternal pre-conception ethanol are reproducible using genetically identical, inbred B6 animals. (C) 2016 Elsevier Inc. All rights reserved.
机译：虽然酒精使用障碍（AUD）是一种高度遗传的条件，但患有酒精中毒历史的家庭的基础难以单独通过遗传变异来解释。新兴的证据表明，受孕前的亲本经验可以影响通过非基因组（表观遗传）机制在后代复杂行为的遗传。例如，暴露于慢性间歇蒸气乙醇（CIE）的雄性C57BL / 6J（B6）小鼠在配毒菌菌株129S1 / SVIMJ乙醇 - 天真的女性中产生雄性后代，其具有降低的乙醇饮用偏好，增加乙醇敏感性和增加的脑衍生腹侧腹侧区域（VTA）中的神经营养因子（BDNF）表达。在本研究中，我们测试了父亲CIE的这些代际作用在近交联系B6背景上的男性后代可重现的这些争论。为此，在与乙醇 - 幼稚B6雌性交配之前，将B6雄性暴露于6周的CIE（或室内空气作为对照），以产生乙醇（E）-Sired和对照（C）的雄性和女性后代。我们观察了一种性别特异性效果，因为电子含量呈现出两瓶自由选择乙醇饮酒偏好，对乙醇的抗焦虑作用增加了敏感性，并且增加了VTA BDNF表达;在女性后代没有观察到差异。这些发现通过证明使用遗传相同的近交B6动物可重复患者预概念乙醇的效果来证实我们以前的结果。 （c）2016年Elsevier Inc.保留所有权利。

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