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Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study

机译:间充质干细胞条件培养基改善牛肝病寻常症:一个案例研究

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Psoriasis, an autoimmune disease, affects a vast number of peoples around the world. In this report, we discuss our findings about a scalp psoriasis suffering patient with a Psoriasis Scalp Severity Index (PSSI) score of 28, who was treated with Mesenchymal stem cell conditioned media (MSC-CM). Remarkably, complete regression was recorded within a treatment period of one month only (PSSI score of 0). A number of bioactive factors like cytokines and growth factors secreted by MSCs in the conditioned medium are very likely to be the principle molecules which play a vital role in skin regeneration. Treatment using MSC-CM appears to be an effective tool for tackling the psoriatic problem and, thus, may offer a new avenue of therapy which could be considered as an alternative approach to overcome the limitations of the cell-based therapy.
机译:牛皮癣是一种自身免疫性疾病,影响了世界各地的大量人民。在本报告中,我们讨论了患有牛皮癣头皮患者的头皮牛皮癣患者的调查结果,其患有间充质干细胞条件培养基(MSC-CM)处理的28分。值得注意的是,在一个月的治疗期内记录完全回归(PSSI得分为0)。在条件培养基中,MSCs分泌的许多生物活性因子等细胞因子和生长因子中可能是在皮肤再生中发挥重要作用的主要分子。使用MSC-CM的处理似乎是解决银屑病问题的有效工具,因此可以提供新的治疗途径,这可以被认为是克服基于细胞疗法的局限性的替代方法。

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