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Evaluation of Cytotoxic Profile of Some Chalcone Derivatives with Antimalarial Properties

机译：用抗体性质评价一些醌衍生物的细胞毒性谱

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Malaria continues to kill thousands of people worldwide. People South of the Sahara are paying the heaviest price for this epidemic. In addition, the resistance of Plasmodium falciparum which spreads to artemisinin derivatives becomes worrying. To respond to this emergency, the search for new molecules effective against the parasite is essential. Otherwise, chalcones have shown their potential as an effective pharmaceutical agent in numerous studies. However, despite their mainly antiparasitic efficacy, several compounds have been shown to be cytotoxic. This study aimed to assess the cytotoxic profile of chalcone derivatives. Cytotoxicity tests were carried out according to the method described by Taylor and collaborators on Vero cells. The 96-well plates were used in carrying out this study, 100 μl of the compounds were added with concentrations ranging from 7.5 to 1000 μg/ml in DMEM. The results obtained report three compounds derivatives (Chal_B14, Chal_B17andChal_SCA03) no-cytotoxic with LDH product values between 129 - 132.5 U/L and ATP ranging from 8.55 to 13.6 RLU. The IC_(50s) for no-cytotoxic compounds ranged from 102 to 236 μM. On the other hand, the cytotoxic compounds had IC_(50s) of less than 30 μM.
机译：疟疾继续杀死全球成千上万的人。撒哈拉南部的人们正在为这一流行病支付最重的价格。此外，蔓延到氨化素衍生物的疟原虫疟原虫的抗性变得令人担忧。为了回应这种紧急情况，对寄生虫有效的新分子的搜索至关重要。否则，Chalcones在许多研究中表明它们是一种有效的药剂。然而，尽管它们主要是抗稀疏性疗效，但已经显示出几种化合物是细胞毒性的。本研究旨在评估硫酮衍生物的细胞毒性谱。根据泰勒和vero细胞上描述的方法进行细胞毒性试验。使用96孔板进行本研究，加入100μl化合物的浓度在DMEM中的7.5至1000μg/ ml。得到的结果报告了三种化合物衍生物（Chal_B14，Chal_B17和Chal_B17andchal_SCA03）No-cytoxic，LDH产物值在129-132.5 U / L和ATP之间的范围为8.55至13.6 RLU。用于无细胞毒性化合物的IC_（50s）的范围为102至236μm。另一方面，细胞毒性化合物具有小于30μm的IC_（50s）。

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