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首页> 外文期刊>Case Reports in Obstetrics and Gynecology >Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus
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Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus

机译：4级患有吉西他滨和多西紫杉醇的患者治疗的患者肺炎治疗子宫的复发性Leiomyosarcoma

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Gemcitabine and docetaxel combination chemotherapy is the standard of care for patients with unresectable recurrent or metastatic leiomyosarcoma of the uterus. Although they are generally well-tolerated agents, they can also cause severe and life-threatening pulmonary toxicities. Here, we describe a case of grade 4 pneumonitis due to gemcitabine and docetaxel in a 74-year-old woman with recurrent, metastatic uterine leiomyosarcoma. Despite early recognition of chemotherapy-induced lung injury and early administration of corticosteroid, she developed noncardiogenic pulmonary edema, diffuse alveolar hemorrhage, and acute respiratory distress syndrome. She required multiple intubations and a tracheostomy. Physicians should not only be aware of gemcitabine and docetaxel’s potential to cause life-threatening pulmonary injuries but also recognize the variability in clinical presentations and treatment responses, the radiographic findings of these lung toxicities, and the need for early corticosteroid therapy in these cases.
机译：吉西他滨和多西紫杉醇组合化疗是子宫不可切除的复发或转移性平滑肌肉瘤患者的护理标准。虽然它们通常是耐受良好的药剂，但它们也可能引起严重和危及生命的肺部毒性。在这里，我们描述了一例的4级肺炎，由于吉西他滨和多西紫杉醇，在一个74岁的女性中复发，转移性子宫平滑肌肉瘤。尽管早期识别化疗诱导的肺损伤和早期施用皮质类固醇，但她开发了非狭窄的肺水肿，弥漫性肺泡出血和急性呼吸窘迫综合征。她需要多次插管和气管造口术。医生不仅要意识到吉西他滨和多西紫杉醇的潜力，造成危及生命的肺部伤害，还要认识到这些肺部毒性的临床介绍和治疗反应的可变性，以及在这些情况下对早期皮质类固醇治疗的需要。

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