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首页> 外文期刊>ACS Omega >Methyl-β-cyclodextrin Inclusion Complex with β-Caryophyllene: Preparation, Characterization, and Improvement of Pharmacological Activities
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Methyl-β-cyclodextrin Inclusion Complex with β-Caryophyllene: Preparation, Characterization, and Improvement of Pharmacological Activities

机译：甲基-β-环糊精包涵体含有β-羧基烯酮：药理活性的制备，表征和改善

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摘要

β-Caryophyllene (BCP) is a sesquiterpene that shows high potential in pharmacological applications. However, these have been drastically limited by the respective volatility and poor water solubility. The present study investigates the formation of inclusion complexes between BCP and methyl-β-cyclodextrin (MβCD) and shows that these complexes promote a significant improvement of the anti-inflammatory, gastric protection, and antioxidant activities relative to neat BCP. It is shown that the solubility of BCP is significantly increased through complexation in phase solubility studies. Inclusion complexes with MβCD in solid state were prepared by three different methods, kneading, rotary evaporation, and lyophilization, with the latter confirmed by differential scanning calorimetry, Fourier transformed infrared spectroscopy, scanning electron microscopy, ~(1)H NMR spectroscopy, and molecular dynamics studies. This study provides for the first time a full characterization of inclusion complexes between BCP and MβCD and highlights the impact of complex formation upon pharmacological activity.
机译：β-亚氰基烯（BCP）是一种在药理应用中显示出高潜力的倍二萜。然而，这些通过各自的挥发性和水溶解度差异急剧限制。本研究研究了BCP和甲基-β-环糊精（MβCD）之间的包合物的形成，并表明这些配合物促进了相对于整齐BCP的抗炎，胃保护和抗氧化活性的显着改善。结果表明，通过相溶解度研究的络合，BCP的溶解度显着增加。通过三种不同的方法，捏合，旋转蒸发和冻干制备具有固态的MβCD的包合物，后者通过差示扫描量热法，傅里叶变换红外光谱，扫描电子显微镜，〜（1）H NMR光谱和分子动力学研究。本研究提供了第一次在BCP和MβCD之间完全表征包合物和MβCD之间的包合物，并突出复杂地层对药理学活性的影响。

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