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首页> 外文期刊>Advances in Sexual Medicine >The Metabolic Syndrome and Sexual Dysfunction in a State of Inflammation
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The Metabolic Syndrome and Sexual Dysfunction in a State of Inflammation

机译：代谢综合征和性功能障碍在炎症状态

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Background: Diabetes is amongst the most researched diseases worldwide due to its debilitating effects on patients. Diabetics have a higher risk of developing erectile dysfunction. Evidence has linked erectile dysfunction severity to increased age, duration of diabetes, the metabolic syndrome and hypogonadism. However, the role of inflammatory markers in the pathogenesis of SD is still unclear. The contributions of hormonal parameters and adipokines to both macro and micro vascular complications are still poorly understood. This study was conducted to provide some evidence of an association between SD, the metabolic syndrome and inflammatory hormones. Method: A total of 130 diabetic males participated in this study. All participants were at least 18 years and were actively engaged in a stable heterosexual relationship for a minimum of two years before they were recruited for this study. The Diabetic men were evaluated using the Golombok Rust Inventory of Sexual Satisfaction for males (GRISS-M). The NCEP-ATP III, IDF and WHO criteria were used to assess the metabolic syndrome. Blood samples were taken for biochemical and hormonal assays. Results: Participants with raised Triglyceride levels showed significantly higher leptin levels for NCEP-ATP III and IDF criteria. Participants with impotence showed significantly lower leptin/adiponectin ratio (p = 0.0184) whilst participant with non-sensuality showed significantly higher values of leptin/adiponectin ratio (p = 0.0103). A significantly higher levels of insulin (p = 0.0265) was recorded in participants with Dissatisfaction problems. Participants with Non communication problems showed significantly higher levels of insulin (p = 0.0419) and lower levels of adiponectin (p = 0.0438) whilst participants with infrequency showed significantly lower levels of adiponectin (p = 0.0042). Conclusion: The relative balance between pro inflammatory and anti-inflammatory mediators of endothelial dysfunction could possibly be essential for the progression of diabetes to SD and the MetS thus a longitudinal study which measures a range of both pro and anti-inflammatory hormones and adipokines as risk factors for SD and the MetS could potentially aid in improvements in assessing the risk of developing these conditions among diabetics.
机译：背景：糖尿病是由于其对患者的衰弱的影响，是全世界的最多研究疾病。糖尿病患者具有更高的开发勃起功能障碍的风险。证据已将勃起功能障碍的严重程度联系起来增加年龄，糖尿病持续时间，代谢综合征和性腺减少症。然而，炎症标志物在SD发病机制中的作用仍然不清楚。激素参数和脂肪因子对宏观和微血管并发症的贡献仍然很清楚。进行该研究以提供SD，代谢综合征和炎症激素之间关联的一些证据。方法：在本研究中共有130名糖尿病雄性。所有参与者至少有18年，并在招聘本研究之前，至少两年积极参与稳定的异性恋关系。糖尿病男性使用雄组的性满意度对男性的性满意度进行评估（Griss-M）。 NCEP-ATP III，IDF和世卫组织标准用于评估代谢综合征。血液样品用于生化和激素测定。结果：升高的甘油三酯水平的参与者显示出NCEP-ATP III和IDF标准的瘦素水平显着提高。阳痿的参与者显着降低瘦素/脂联素比（P = 0.0184），而非感性的参与者表现出显着较高的瘦素/脂联素比值（P = 0.0103）。在参与者中记录了胰岛素显着更高水平的胰岛素（P = 0.0265），对参与者进行了不满问题。非沟通问题的参与者显示出较高水平的胰岛素（P = 0.0419），脂肪蛋白的较低水平（P = 0.0438），而富频的参与者显示出显着较低的脂联素（P = 0.0042）。结论：内皮功能障碍的临炎和抗炎介质之间的相对平衡可能对SD糖尿病的进展至关重要，因此是一项纵向研究，纵向研究衡量了一系列Pro和抗炎激素和Adipokines作为风险SD和MET的因素可能有助于改善评估糖尿病患者在糖尿病患者中发展这些病症的风险。

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