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首页> 外文期刊>African Journal of Biotechnology >Cytotoxic effect induced by Morinda morindoides leaf extracts in human and murine leukemia cells
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Cytotoxic effect induced by Morinda morindoides leaf extracts in human and murine leukemia cells

机译：Morinda morindoides叶提取物在人和鼠白血病细胞中诱导的细胞毒性作用

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We report here the?in vitro?effect of the toluene,?methyl tert-buthyl ether?(MtBE),ethyl acetate?(EtOAc),?n-buthanol?(n-BuOH) and H2O? extracts from?Morinda morindoides?(rubiaceae) leaves against a human leukemic cell line, K562, and two murine leukemic cell lines, P388 and L1210. We found that both toluene and MtBE extracts exhibited a significant cytotoxic effect on these murine cell lines. The highest cytotoxicity was obtained with toluene extract in P388 (6.0 ± 1.4 μg/ml) and L1210 cells (6.5 ± 2.1 μg/ml). By contrast, EtOAc, n-BuOH and H2O extracts did not affect cell viability of the three cell lines tested. Effect of toluene and MtBE extracts was also examined on apoptosis induction in K562 human erythroleukemia cells. The results of this preliminary study have shown that the cytotoxic effects of toluene and MtBE extracts from?Morinda morindoides?leaves observed in K562 cells were mediated through the induction of apoptosis. Possible mechanisms responsible for the induction of apoptosis are discussed.
机译：我们在此报告吗？体外甲苯的作用，α甲基叔丁基醚α（MTBE），乙酸乙酯？（EtOAc），α（N-Buh）和H2O？来自？Morinda Morindoides的提取物（RubiaCeae）叶对抗人白血病细胞系，K562和两只小鼠白血病细胞系P388和L1210。我们发现，甲苯和MTBE提取物都对这些鼠细胞系具有显着的细胞毒性作用。在P388（6.0±1.4μg/ mL）和L1210细胞（6.5±2.1μg/ ml）中，在甲苯提取物中获得最高细胞毒性。相比之下，EtOAc，N-BuOH和H 2 O提取物不影响测试的三种细胞系的细胞活力。甲苯和MTBE提取物的效果也在K562人赤瘤气孔细胞中的凋亡诱导上进行研究。该初步研究的结果表明，甲苯和MTBE提取物的细胞毒性作用来自莫琳达·莫宁骨蛋白β·莫宁蛋白蛋白β叶片在K562细胞中观察到的叶片通过诱导细胞凋亡介导。讨论了负责诱导细胞凋亡的可能机制。

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