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首页> 外文期刊>International Journal of Environmental Research and Public Health >Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes
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Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes

机译：无论患有糖尿病或患有糖尿病患者外周血动脉闭塞性疾病的踝脑 - 肱胸腺指数变化的独立因素

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Peripheral arterial disease (PAD) belongs to the commonly-occurring pathologies associated with elderly age. A simple tool for defining the severity of PAD is the ankle-brachial index (ABI). The purpose of this research was to determine independent factors of changes of ABI in elderly patients with occlusive PAD disease (PAOD) with and without diabetes. The research was carried out on 49 elderly patients with PAOD, including 29 patients with type 2 diabetes, and 20 patients without diabetes. The concentration of interleukin-6 (IL-6), E-selectin, fibrinogen, and C-reactive protein (CRP) in the blood serum was marked. In all patients, the independent factors of changes of ABI were determined with the use of the multiple logistic regression analysis. Our results show that in the group of patients with PAOD suffering from diabetes, it was demonstrated that the ABI was related to age, the duration of the symptoms of PAD, body mass index (BMI), low-density lipoprotein cholesterol, fibrinogen, and sex (determination coefficient R2 = 0.699). In patients with PAOD without diabetes, the ABI was related to age, the duration of the symptoms of PAD, the levels of CRP, E-selectin, high-density lipoprotein cholesterol, and the glomerular filtration rate(determination coefficient R2 = 0.844). We conclude that in elderly patients with PAOD with and without diabetes, the participation of independent factors related to the ABI is diversified; in patients with diabetes, the concentration of IL-6 and fibrinogen is lower, and the concentration of E-selectin is higher than in patients without diabetes.
机译：外周动脉疾病（PAD）属于与老年人相关的普通出现的病理学。用于定义垫的严重性的简单工具是脚踝 - 肱索引（ABI）。该研究的目的是确定老年患者ABI变化的独立因素，无糖尿病和没有糖尿病的闭塞垫疾病（PAOD）。该研究是在49名老年患者的PAOD患者中进行，其中29例患有2型糖尿病患者，20例没有糖尿病患者。血液血清中白细胞介素-6（IL-6），E-SELIEN，纤维蛋白原和C反应蛋白（CRP）的浓度标记为。在所有患者中，使用多元逻辑回归分析确定ABI变化的独立因素。我们的研究结果表明，在患有糖尿病的Paod患者组中，证明ABI与年龄有关，垫的症状持续时间，体重指数（BMI），低密度脂蛋白胆固醇，纤维蛋白原和纤维蛋白原和性（确定系数R2 = 0.699）。在没有糖尿病的PAOD患者中，ABI与年龄有关，垫的症状持续时间，CRP，E-SELETIN，高密度脂蛋白胆固醇的水平和肾小球过滤速率（测定系数R2 = 0.844）。我们得出结论，在老年患有糖尿病和没有糖尿病的老年患者中，与ABI相关的独立因素的参与是多元化的;在糖尿病患者中，IL-6和纤维蛋白原的浓度较低，E-SELETIN的浓度高于没有糖尿病的患者。

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