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A Review on Currently Available Potential Therapeutic Options for COVID-19

机译：关于Covid-19目前可用的潜在治疗选择的综述

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A series of unexplained pneumonia cases currently were first reported in December 2019 in Wuhan, China. Official names have been announced for the virus responsible, previously known as “ 2019 novel coronavirus” and the diseases it causes are, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19), respectively. Despite great efforts worldwide to control SARS-CoV-2, the spread of the virus has reached a pandemic. Infection prevention and control of this virus is the primary concern of public health officials and professionals. Currently, several therapeutic options for COVID-19 are proposed and vaccine development has been initiated for prevention purposes. In this review, we will discuss the most recent evidence about the current potential treatment options including anti-inflammatory drugs, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, nucleoside analogs, protease inhibitors, monoclonal antibodies, and convalescent plasma therapy. Some other agents such as vitamin D and melatonin, which were recommended as potential adjuvant treatments for COVID-19 infection are also presented. Moreover, the potential use of convalescent plasma for treatment of COVID-19 infection was described. Furthermore, in the next part of the current review, various vaccination approaches against COVID-19 including whole virus vaccines, recombinant subunit vaccine, DNA vaccines, and mRNA vaccines are discussed.
机译：目前在2019年12月在中国武汉首次报道了一系列未解释的肺炎案例。官方名称已宣布负责的病毒，以前称为“2019年新冠状病毒”，疾病分别是严重的急性呼吸综合征冠状病毒2（SARS-COV-2）和冠状病毒（Covid-19）。尽管全球努力控制SARS-COV-2，但病毒的蔓延已经达到了大流行。这种病毒的感染预防和控制是公共卫生官员和专业人士的主要关注点。目前，提出了几种Covid-19治疗选择，并已启动疫苗开发以预防目的。在本文中，我们将讨论关于当前潜在治疗选择的最新证据，包括抗炎药，血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂，核苷类似物，蛋白酶抑制剂，单克隆抗体和临时血浆治疗。还提出了一些其他药剂，如维生素D和褪黑激素，这是暗指Covid-19感染的潜在佐剂处理。此外，描述了临时血浆用于治疗Covid-19感染的潜在使用。此外，在目前审查的下一部分中，讨论了对Covid-19的各种疫苗接种方法，包括整个病毒疫苗，重组亚基疫苗，DNA疫苗和mRNA疫苗。

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