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首页> 外文期刊>International Journal of Research in Medical Sciences >To evaluate the role of sputum in the diagnosis of lung cancer in south Indian population
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To evaluate the role of sputum in the diagnosis of lung cancer in south Indian population

机译：评估痰在南印度人口肺癌诊断中的作用

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Background: The main advantage of sputum cytology is its simplicity, non-invasiveness and minimal discomfort to the patient. Though, the sputum is evaluated in the diagnosis of lung cancer, the report on the same in the South Indian population was lacking. Therefore, the present study has been undertaken to evaluate the role of sputum in the diagnosis of lung cancer in South Indian population. Methods: The material consisted of sputum samples from 133 patients and was collected in clean wide mouthed disposable plastic containers. Patients were asked to collect sputum the next morning after washing the mouth properly. The sputum was immediately brought to the laboratory and poured into a watch glass. Four smears were prepared from each sample, out of which two smears were immediately fixed in methanol and the other two were air-dried. The methanol fixed smears were stained with Papanicolaou stain. Out of the two air dried smears, one was stained with May Grunwald Giemsa and the other with Gabbot's method for AFB. The smears were screened for malignant cells and a cytological diagnosis was made. The cytological diagnosis was correlated with the histopathological diagnosis. The data obtained were represented as mean percentages. Results: The observation of sputum smears showed numerous pleiomorphic keratinized squamous cells, keratinized squamous cell with hyper chromatic nucleus in well differentiated squamous cell carcinoma, pleiomorphic cells having vacuolated cytoplasm and vesicular nucleus with prominent nucleoli as in adenocarcinoma of the lung, cells arranged in small clusters and having scanty cytoplasm in small cell carcinoma and cells are slightly larger than lymphocyte with scanty cytoplasm and hyper chromatic, grooved nuclei in small cell carcinoma. Conclusion: Cytology of sputum is extremely useful and highly sensitive. The diagnostic accuracy is directly proportional to the number of samples. Sputum cytology is highly sensitive for the centrally located squamous cell carcinoma rather than the peripherally located adenocarcinoma. Properly collected, simple sputum examination alone can give results similar to other highly expensive methods like bronchoscopic material for the diagnosis of lung cancer.
机译：背景：痰细胞学的主要优点是其简单性，非侵袭性和对患者的极少不适。虽然，痰被评估在肺癌的诊断中，缺乏南印度人群的同样的报告。因此，已经进行了本研究，以评估痰液在南印度人群肺癌诊断中的作用。方法：该材料由来自133名患者的痰样品组成，并在清洁宽口的一次性塑料容器中收集。患者被要求在第二天早上妥善洗漱后第二天早上收集痰。痰液立即带到实验室并倒入手表玻璃上。从每个样品中制备四种涂片，其中两个涂片立即固定在甲醇中，另外两个空气干燥。甲醇固定的涂片染色用帕帕内尼乳杆菌染色。在两种空气干燥的涂片中，一个用5月Grunwald Giemsa染色，另一个是Gabbot的AFB方法。对恶性细胞进行筛缝进行涂片，并进行了细胞学诊断。细胞学诊断与组织病理学诊断相关。所获得的数据表示为平均百分比。结果：痰涂片的观察显示了许多肝脏角化鳞状细胞，具有良好的鳞状细胞癌中具有超色细胞核的角质化鳞状细胞，具有真菌细胞质和脉络细胞核，具有突出的核细胞核，如肺癌的腺癌，细胞排列小细胞癌和细胞中具有痕量细胞质的簇略大于小细胞癌中具有稀释细胞质和高彩色，沟槽核的淋巴细胞略大于淋巴细胞。结论：痰的细胞学是非常有用和高敏感的。诊断精度与样本数量成正比。痰细胞学对中心位于鳞状细胞癌而不是外周位于腺癌的浓度高度敏感。妥善收集，单独的简单痰检查可以给出类似于其他高度昂贵的方法，如支气管镜材料，用于诊断肺癌。

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