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首页> 外文期刊>Italian Journal of Medicine >Compliance with the clinical practice guidelines for the management of hepatitis B and C virus-related chronic liver disease: a survey based on hospitalized cirrhotic patients
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Compliance with the clinical practice guidelines for the management of hepatitis B and C virus-related chronic liver disease: a survey based on hospitalized cirrhotic patients

机译：遵守乙型肝炎和C病毒相关慢性肝病管理的临床实践指南：基于住院患者的肝硬化患者的调查

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In recent years, significant progress has been made in furthering our knowledge of chronic liver disease (CLD) and evaluating the therapeutic approaches. These have been updated in the form of recommendations by international scientific societies. Through a retrospective analysis, this study aimed to verify whether these recommendations have been applied in real practice. The study design included data gathered from all patients consecutively hospitalized for decompensated liver cirrhosis during one year. A pre-made master form was used to record data on the patients’ past knowledge of the etiology and management of their liver disease. As expected, hepatitis C virus (HCV) was the most frequent cause of CLD, while 41 cases were cryptogenic. In 69 of 263 patients with HCV infection, viral genotyping had been performed, although only 39 of these cases had been treated. Only 3 of 44 patients suffering from hepatitis B virus (HBV)-related liver cirrhosis had been treated in the past, while 11 patients were still being treated. Among the remaining patients, 15 were not aware that they had CLD and 15 had never been considered for antiviral treatment. In 81 cases, the disease had progressed to hepatocellular carcinoma, but only 19 patients had discovered the tumor following regular ultrasound screening. Thirty-seven patients were receiving specific treatment consistent with the stage of their disease. The management of HBV- and HCV-related CLD in Sicily is far from optimal, and although the natural history and management practices of these diseases are well known, this knowledge is a long way from being applied in our daily practice.
机译：近年来，促进了我们对慢性肝病（CLD）的知识并评估治疗方法的重大进展。这些已由国际科学社会以建议的形式更新。通过回顾性分析，本研究旨在验证这些建议是否已在实际实践中应用。研究设计包括在一年内为二元肝硬化的所有患者收集的数据收集。预先制造的母版本用于记录患者过去知识的数据和肝脏病的病因和管理的数据。正如预期的那样，丙型肝炎病毒（HCV）是CLD中最常见的原因，而41例是密码发生的。在263例HCV感染患者中，已经进行了病毒基因分型，但这些病例中只有39例已经治疗。过去只治疗了44例患有乙型肝炎病毒（HBV）相关肝硬化的44名患者中的3例，而11名患者仍在治疗。在剩下的患者中，15名并不意识到他们有CLD和15人从未考虑过抗病毒治疗。在81例患者中，该疾病已进入肝细胞癌，但只有19名患者发现了常规超声波筛查后的肿瘤。三十七名患者接受与疾病阶段一致的特定治疗。在西西里岛的HBV和HCV相关CLD管理远非最佳，尽管这些疾病的自然历史和管理实践是众所周知的，但这种知识是在我们日常生法中应用的漫长方法。

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