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首页> 外文期刊>Digestive Diseases and Sciences >Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody.
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Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody.

机译：抗着丝粒抗体阳性的丙型肝炎病毒相关慢性肝病患者的临床特征。

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摘要

The association between anticentromere antibody (ACA) and hepatitis C virus (HCV) infection remains unclear. We subjected eight patients with HCV-related chronic liver disease (CLD) seropositive for ACA to a battery of clinical and laboratory tests. The patient cohort was dominated by females, and four of the eight (50%) patients had a concomitant autoimmune disease. All of the patients had high titers of ACA (>or=1:320). The histological activity index scores in chronic hepatitis C (CH-C) patients with ACA were significantly higher than those in CH-C patients without antinuclear antibody (ANA) (12.8 +/- 1.8 vs. 8.3 +/- 4.5, P = 0.0372). The frequency of human leukocyte antigen (HLA) DR-8 in patients with HCV-related CLD seropositive for ACA was significantly higher than that in patients with CH-C seronegative for ANA (71 vs. 18%, P = 0.0108). These findings suggest that ACA is induced by chronic HCV infection in association with HLA DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and inflammation than CH-C patients without ANA.
机译：抗着丝粒抗体（ACA）和丙型肝炎病毒（HCV）感染之间的关联仍不清楚。我们对八名患有HCV相关性慢性肝病（CLD）阳性的ACA患者进行了一系列临床和实验室测试。患者队列以女性为主，八名患者中有四名（50％）伴有自身免疫病。所有患者均具有较高的ACA滴度（>或= 1：320）。患有ACA的慢性丙型肝炎（CH-C）患者的组织学活动指数评分显着高于未使用抗核抗体（ANA）的CH-C患者（12.8 +/- 1.8 vs. 8.3 +/- 4.5，P = 0.0372 ）。 HCV相关CLD血清阳性的ACA患者中人白细胞抗原（HLA）DR-8的频率显着高于ANA血清阴性的CH-C患者（71％vs. 18％，P = 0.0108）。这些发现表明，与HLA DR-8相关的慢性HCV感染可诱导ACA，与无ANA的CH-C患者相比，具有ACA的CH-C患者表现出更严重的肝纤维化和炎症。

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