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首页> 外文期刊>Iranian Journal of Neurology >Association between single nucleotide polymorphisms rs12722489 and multiple sclerosis in Iranian patients with multiple sclerosis
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Association between single nucleotide polymorphisms rs12722489 and multiple sclerosis in Iranian patients with multiple sclerosis

机译：单核苷酸多态性rs12722489与多发性硬化症患者的多核苷酸多态性rs12722489之间的关系

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Abstract Background: Multiple sclerosis (MS) is a complex incurable neurodegenerative disease featuring demyelination of neurons, resulting in impairment of neuron impulses. Recently, an association of two single nucleotide polymorphisms (SNP) (rs2104286 and rs12722489) in interleukin 2 receptor subunit alpha (IL2RA) gene was found to be a risk factor of MS in white European population. Therefore, we performed a study to investigate the contribution of these two intronic variations in Iranian patients with MS. Methods: We determined the genotypes of rs2104286 and rs12722489 in patients with MS (n = 100) and in the control group (n = 111). The SNPs were genotyped using tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) for both of SNPs. Statistical analysis was performed by SPSS software. Also, odds ratios (ORs) and 95% confidence interval (CI) were calculated. Results: Logistic regression revealed that various genotypes of rs12722489, regarding sex-adjusted effect, yielded meaningful association with MS risk in Iranian patients (OR = 2.67, 95% CI: 1.03-6.90). However, no association was obtained for rs2104286 and rs12722489 with MS. Conclusion: The results confirmed partially the reports in white European population performed recently. However, further investigation in larger scale is necessary to validate our study.
机译：摘要背景：多发性硬化症（MS）是一种复杂的可治区神经变性疾病，具有神经元脱髓鞘，导致神经元脉冲的损害。最近，在白细胞介素2受体亚基α（IL2RA）基因中，两种单一核苷酸多态性（SNP）（SNP）（RS2104286和RS12722489）的关联是白欧洲人群MS的危险因素。因此，我们进行了一项研究，以调查这两种内华患者患者患者患者的贡献。方法：我们确定了MS（n = 100）和对照组（n = 111）的患者中RS2104286和RS1272489的基因型。使用Tetra-infer扩增难敏突变体系 - 聚合酶链反应（T-Arms-PCR）对SNP进行基因分型进行基因分型。 SPSS软件执行统计分析。此外，计算了大量比率（或）和95％置信区间（CI）。结果：逻辑回归显示，关于性别调整效应，rs1272489的各种基因型与伊朗患者的MS风险产生了有意义的关联（或= 2.67,95％CI：1.03-6.90）。但是，没有为RS2104286和MS的RS12722489获得关联。结论：结果确认了白欧洲人口最近的报告。然而，需要进一步调查较大规模的验证我们的研究。

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