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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
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CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.

机译：CTLA-4和多发性硬化：A49G单核苷酸多态性与南澳大利亚州人群的多发性硬化无关。

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摘要

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
机译：多发性硬化症（MS）是一种慢性自身免疫性疾病，可引起中枢神经系统（CNS）的炎症性脱髓鞘和轴突损伤。我们调查了CTLA-4基因的A49G单核苷酸多态性（SNP）基因型是否影响了南澳大利亚人MS的发育以及该SNP与DRB1 * 15单倍型的相互作用。在分层之前或之后，由于存在DR15单倍型，A49G基因型与MS风险之间无显着相关性（P <0.05）。

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